Winthrop Kevin L, Albridge Kim, South David, Albrecht Peggy, Abrams Marcy, Samuel Michael C, Leonard Wendy, Wagner Joanna, Vugia Duc J
Epidemic Intelligence Service, Centers for Disease Control and Prevention at the California Department of Health Services, Berkeley, California 94704, USA.
Clin Infect Dis. 2004 Jan 1;38(1):38-44. doi: 10.1086/380459. Epub 2003 Dec 8.
Nontuberculous mycobacterial infections are becoming more common. Recently, Mycobacterium fortuitum and other rapidly growing mycobacteria have been found to cause severe skin and soft-tissue infections in association with nail salon whirlpool footbaths. We recently investigated a large outbreak of M. fortuitum furunculosis among women who received pedicures at a single nail salon. To better define the clinical course of such infections, we collected clinical details from physicians who were treating outbreak patients. We constructed multivariable linear models to evaluate the effect of antibiotic treatment on disease duration. Sixty-one patients were included in the investigation. The mean disease duration was 170 days (range, 41-336 days). Forty-eight persons received antibiotic therapy for a median period of 4 months (range, 1-6 months), and 13 persons were untreated. Isolates were most susceptible to ciprofloxacin and minocycline. Early administration of therapy was associated with shorter duration of disease only in persons with multiple boils (P<.01). One untreated, healthy patient had lymphatic disease dissemination.
非结核分枝杆菌感染正变得越来越常见。最近，偶然分枝杆菌和其他快速生长的分枝杆菌已被发现与美甲店漩涡式足浴盆相关，可引起严重的皮肤和软组织感染。我们最近调查了在一家美甲店接受足疗的女性中发生的一次大规模偶然分枝杆菌疖病暴发。为了更好地确定此类感染的临床过程，我们从治疗暴发患者的医生那里收集了临床细节。我们构建了多变量线性模型来评估抗生素治疗对疾病持续时间的影响。61名患者被纳入调查。平均疾病持续时间为170天（范围为41 - 336天）。48人接受了抗生素治疗，中位治疗期为4个月（范围为1 - 6个月），13人未接受治疗。分离株对环丙沙星和米诺环素最敏感。仅在有多发性疖肿的患者中，早期给予治疗与较短的疾病持续时间相关（P<0.01）。一名未接受治疗的健康患者出现了淋巴管疾病播散。
