载脂蛋白E基因多态性与冠心病关系的Meta分析
[Meta-analysis for relationship between apoE gene polymorphism and coronary heart disease].
作者信息
Wang Chun-Hong, Zhou Xin
机构信息
Department of Hygiene, School of Public Health, Wuhan University, Wuhan 430071, China.
出版信息
Zhonghua Yu Fang Yi Xue Za Zhi. 2003 Sep;37(5):368-70.
OBJECTIVE
To evaluate relationship between ApoE gene polymorphism and coronary heart disease (CHD).
METHODS
Meta-analysis was applied with a random-effect model for the collected data.
RESULTS
Difference in pooled frequencies, d, of apoE genotypes E3/2, E4/2, E3/3, E4/3 and E4/4 between case and control groups were 2.3%, -0.8%, -8.5%, 10.5% and 0.9%, respectively. Difference in pooled frequencies, d, of apoE alleles epsilon2, epsilon3 and epsilon4 were -1.5%, -4.2% and 5.8%, respectively, with a statistical significance between four groups.
CONCLUSIONS
apoE gene polymorphism was involved in coronary heart disease. Persons with apoE E3/3 genotype or epsilon3 allele were not susceptible to CHD, but those with apoE E4/4 genotype or epsilon4 allele had higher risk suffering from CHD than others.
目的
评估载脂蛋白E（ApoE）基因多态性与冠心病（CHD）之间的关系。
方法
对收集的数据采用随机效应模型进行Meta分析。
结果
病例组与对照组之间载脂蛋白E基因型E3/2、E4/2、E3/3、E4/3和E4/4的合并频率差异d分别为2.3%、-0.8%、-8.5%、10.5%和0.9%。载脂蛋白E等位基因ε2、ε3和ε4的合并频率差异d分别为-1.5%、-4.2%和5.8%，四组之间具有统计学意义。
结论
载脂蛋白E基因多态性与冠心病有关。载脂蛋白E E3/3基因型或ε3等位基因的个体不易患冠心病，但载脂蛋白E E4/4基因型或ε4等位基因的个体患冠心病的风险高于其他人。
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