Brenner Hermann, Hakulinen Timo
Department of Epidemiology, German Centre for Research on Ageing, Bergheimer Strasse 20, D-69115, Heidelberg, Germany.
J Clin Epidemiol. 2003 Dec;56(12):1185-91. doi: 10.1016/s0895-4356(03)00209-9.
Relative survival rates, such as 5- or 10-year relative survival rates, which quantify "net survival" of cancer patients, are the most commonly reported measures of cancer outcome by cancer registries. Because relative survival rates vary with age for many forms of cancer, and because the age distribution of cancer patients varies between different populations or within one population over time, age adjustment of relative survival rates is often employed in international comparisons or in time series analyses of cancer patient survival. In this article, we show that derivation of crude and of age-adjusted relative survival rates in the traditional way is conceptually inconsistent, and that this inconsistency has important practical implications. We show ways to overcome this inconsistency in the derivation and interpretation of crude and age-adjusted relative survival rates.
相对生存率，如5年或10年相对生存率，用于量化癌症患者的“净生存率”，是癌症登记处最常报告的癌症预后指标。由于多种癌症的相对生存率随年龄而异，且不同人群之间或同一人群随时间推移癌症患者的年龄分布有所不同，因此在国际比较或癌症患者生存时间序列分析中，常采用相对生存率的年龄调整方法。在本文中，我们表明，传统方式下粗相对生存率和年龄调整相对生存率的推导在概念上不一致，且这种不一致具有重要的实际意义。我们展示了在粗相对生存率和年龄调整相对生存率的推导及解释中克服这种不一致的方法。
