• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

胸腺细胞表达一种与下丘脑促黄体生成素释放激素信使核糖核酸相同的信使核糖核酸。

Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA.

作者信息

Maier C C, Marchetti B, LeBoeuf R D, Blalock J E

机构信息

Department of Physiology and Biophysics, University of Alamaba, Birmingham 35294-0005.

出版信息

Cell Mol Neurobiol. 1992 Oct;12(5):447-54. doi: 10.1007/BF00711545.

DOI:10.1007/BF00711545
PMID:1468115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11567407/
Abstract
  1. A luteinizing hormone-releasing hormone (LHRH)-like molecule produced by thymocytes is similar to hypothalamic LHRH in both bioactivity and antigenicity. 2. We determined whether this thymic LHRH is identical to or only homologous with hypothalamic LHRH by synthesizing and sequencing the cDNA of rat thymus LHRH. 3. The thymocyte and hypothalamic LHRH cDNAs are identical, indicating, that the amino acid sequences of LHRH produced in the hypothalamus and the immune system are also identical. 4. This is the first report showing conclusively that cell of the immune system transcribe the authentic mRNA for a hypothalamic releasing factor, LHRH.
摘要
  1. 胸腺细胞产生的一种促黄体生成激素释放激素（LHRH）样分子在生物活性和抗原性方面均与下丘脑LHRH相似。2. 我们通过合成和测序大鼠胸腺LHRH的cDNA来确定这种胸腺LHRH与下丘脑LHRH是完全相同还是仅具有同源性。3. 胸腺细胞和下丘脑LHRH的cDNA是相同的，这表明下丘脑和免疫系统产生的LHRH的氨基酸序列也是相同的。4. 这是第一份确凿表明免疫系统细胞转录下丘脑释放因子LHRH真实mRNA的报告。

相似文献

1
Thymocytes express a mRNA that is identical to hypothalamic luteinizing hormone-releasing hormone mRNA.胸腺细胞表达一种与下丘脑促黄体生成素释放激素信使核糖核酸相同的信使核糖核酸。
Cell Mol Neurobiol. 1992 Oct;12(5):447-54. doi: 10.1007/BF00711545.
2
Expression of luteinizing hormone-releasing hormone and its receptor in porcine immune tissues.
Life Sci. 1997;61(17):1643-9. doi: 10.1016/s0024-3205(97)00769-8.
3
The effect of castration on steady state levels of luteinizing hormone-releasing hormone (LHRH) mRNA and proLHRH processing: time course study utilizing semi-quantitative reverse transcription/polymerase chain reaction.去势对促黄体生成激素释放激素（LHRH）mRNA稳态水平及前LHRH加工的影响：利用半定量逆转录/聚合酶链反应的时间进程研究
J Endocrinol. 1996 Mar;148(3):509-15. doi: 10.1677/joe.0.1480509.
4
The role of gonadectomy and testosterone replacement on thymic luteinizing hormone-releasing hormone production.性腺切除术及睾酮替代疗法对胸腺促黄体生成素释放激素产生的作用。
J Endocrinol. 1998 Aug;158(2):229-35. doi: 10.1677/joe.0.1580229.
5
Presence of luteinizing hormone-releasing hormone (LHRH) mRNA in rat spleen lymphocytes.大鼠脾脏淋巴细胞中促黄体生成激素释放激素（LHRH）mRNA的存在。
Endocrinology. 1991 Mar;128(3):1679-81. doi: 10.1210/endo-128-3-1679.
6
Hypothalamic control of mitogen-induced proliferative responses and luteinizing hormone-releasing hormone levels in thymus and peripheral blood of rat fetuses.下丘脑对大鼠胎儿胸腺和外周血中丝裂原诱导的增殖反应及促黄体生成素释放激素水平的控制。
Neuroimmunomodulation. 2005;12(2):85-91. doi: 10.1159/000083580.
7
Coupled reverse transcription-polymerase chain reaction (RT-PCR) technique is comparative, quantitative, and rapid: uses in alcohol research involving low abundance mRNA species such as hypothalamic LHRH and GRF.逆转录聚合酶链反应（RT-PCR）技术具有比较性、定量性且快速：可用于涉及低丰度mRNA种类（如下丘脑促黄体生成素释放激素和生长激素释放因子）的酒精研究。
Alcohol. 1993 May-Jun;10(3):185-9. doi: 10.1016/0741-8329(93)90033-k.
8
Expression of the messenger RNAs for luteinizing hormone-releasing hormone (LHRH) and its receptor in human ovarian epithelial carcinoma.促黄体生成激素释放激素（LHRH）及其受体的信使核糖核酸在人卵巢上皮癌中的表达
Cancer Res. 1995 Feb 15;55(4):817-22.
9
Examination of guinea pig luteinizing hormone-releasing hormone gene reveals a unique decapeptide and existence of two transcripts in the brain.对豚鼠促黄体生成激素释放激素基因的检测揭示了一种独特的十肽以及大脑中两种转录本的存在。
Endocrinology. 1997 Oct;138(10):4123-30. doi: 10.1210/endo.138.10.5454.
10
Luteinizing hormone-releasing hormone-binding sites in the rat thymus: characteristics and biological function.大鼠胸腺中促黄体生成激素释放激素结合位点：特性与生物学功能
Endocrinology. 1989 Aug;125(2):1025-36. doi: 10.1210/endo-125-2-1025.

引用本文的文献

1
Hypothalamic neurohormones and immune responses.下丘脑神经激素与免疫反应。
Front Integr Neurosci. 2013 Aug 13;7:56. doi: 10.3389/fnint.2013.00056. eCollection 2013.
2
The forkhead transcription factor, FOXP3, is required for normal pituitary gonadotropin expression in mice.叉头框转录因子 FOXP3 是正常小鼠垂体促性腺激素表达所必需的。
Biol Reprod. 2012 May 10;86(5):144, 1-9. doi: 10.1095/biolreprod.111.094904. Print 2012 May.
3
Cross-talk between luteinizing hormone-releasing hormone (LHRH) neurons and astroglial cells: developing glia release factors that accelerate neuronal differentiation and stimulate LHRH release from GT(1-1) neuronal cell line and LHRH neurons induce astroglia proliferation.促黄体生成素释放激素（LHRH）神经元与星形胶质细胞之间的相互作用：发育中的胶质细胞释放加速神经元分化并刺激GT(1-1)神经元细胞系释放LHRH的因子，且LHRH神经元诱导星形胶质细胞增殖。
Endocrine. 1995 Dec;3(12):863-74. doi: 10.1007/BF02738891.
4
Neuroendocrineimmunology (NEI) at the turn of the century: towards a molecular understanding of basic mechanisms and implications for reproductive physiopathology.世纪之交的神经内分泌免疫学（NEI）：迈向对基本机制的分子理解及其对生殖生理病理学的影响。
Endocrine. 1995 Dec;3(12):845-61. doi: 10.1007/BF02738890.
5
Mast cells in the rat brain synthesize gonadotropin-releasing hormone.大鼠脑中的肥大细胞合成促性腺激素释放激素。
J Neurobiol. 2003 Aug;56(2):113-24. doi: 10.1002/neu.10220.

本文引用的文献

1
Purification of biologically active globin messenger RNA by chromatography on oligothymidylic acid-cellulose.通过寡聚胸苷酸纤维素柱层析法纯化具有生物活性的珠蛋白信使核糖核酸。
Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12. doi: 10.1073/pnas.69.6.1408.
2
Human luteinizing hormone-releasing hormone gene (LHRH) is located on short arm of chromosome 8 (region 8p11.2----p21).人类促黄体生成激素释放激素基因（LHRH）位于8号染色体短臂（区域8p11.2----p21）。
Somat Cell Mol Genet. 1986 Jan;12(1):95-100. doi: 10.1007/BF01560732.
3
Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.人及大鼠促性腺激素释放激素与催乳素释放抑制因子共同前体的基因及下丘脑互补脱氧核糖核酸的分离
Proc Natl Acad Sci U S A. 1986 Jan;83(1):179-83. doi: 10.1073/pnas.83.1.179.
4
Luteinizing hormone-releasing hormone (LHRH) agonist restoration of age-associated decline of thymus weight, thymic LHRH receptors, and thymocyte proliferative capacity.促黄体生成素释放激素（LHRH）激动剂可恢复与年龄相关的胸腺重量、胸腺LHRH受体及胸腺细胞增殖能力的下降。
Endocrinology. 1989 Aug;125(2):1037-45. doi: 10.1210/endo-125-2-1037.
5
A molecular basis for bidirectional communication between the immune and neuroendocrine systems.免疫与神经内分泌系统之间双向通信的分子基础。
Physiol Rev. 1989 Jan;69(1):1-32. doi: 10.1152/physrev.1989.69.1.1.
6
The rat gonadotropin-releasing hormone: SH locus: structure and hypothalamic expression.大鼠促性腺激素释放激素：SH基因座：结构与下丘脑表达。
Mol Endocrinol. 1989 Aug;3(8):1257-62. doi: 10.1210/mend-3-8-1257.
7
Corticotrophin-releasing factor-like immunoreactivity and mRNA in human leukocytes.人白细胞中的促肾上腺皮质激素释放因子样免疫反应性和信使核糖核酸
Brain Behav Immun. 1990 Mar;4(1):67-73. doi: 10.1016/0889-1591(90)90007-d.
8
Immunoreactive growth hormone-releasing hormone in rat leukocytes.
J Neuroimmunol. 1990 Sep-Oct;29(1-3):1-13. doi: 10.1016/0165-5728(90)90142-a.
9
Isolation and characterization of the human gonadotropin-releasing hormone gene in the hypothalamus and placenta.人下丘脑和胎盘促性腺激素释放激素基因的分离与鉴定。
Mol Endocrinol. 1990 Mar;4(3):476-80. doi: 10.1210/mend-4-3-476.
10
Rat spleen lymphocytes contain an immunoactive and bioactive luteinizing hormone-releasing hormone.
Endocrinology. 1990 May;126(5):2482-6. doi: 10.1210/endo-126-5-2482.