Granov D A, Pavlovskiĭ A V, Tarazov P G
Central Research Institute of Roentgeno-Radiology, Ministry of Health of the RF, St. Petersburg.
Vopr Onkol. 2003;49(5):579-84.
A novel method of intra-arterial oily chemoembolization of pancreatic tumor has been developed. It slowed down regional blood flow in tumor dramatically due to injection of gemcitabin-in-oil. As a result, a prolonged contact of tumor with the highly-concentrated chemotherapeutic drug along the microcirculatory bed was assured. Enhanced antitumor effect, unaccompanied by any increase in systemic toxicity, was obtained by intensifying gemcitabin perfusion in the tissue. Tumor vessels had to be contrast-enhanced during the selective angiography of great vessels feeding the pancreas. Diagnostic angiography was performed in 63 patients with locally advanced tumors (T4NxMo) in 1999-2002. A total of 98 intra-arterial oily chemoembolizations (1-11 per patient) were carried out in 32 (51%). One or two-year survival rates in these patients after hemzar were 50 and 15%, respectively. Arterial oily chemoembolization is a safe and potentially effective method for the treatment of pancreatic cancer.
一种新型的胰腺肿瘤动脉内油性化疗栓塞方法已被开发出来。由于注射了载药吉西他滨油剂，它显著减缓了肿瘤区域的血流。结果，确保了肿瘤与高浓度化疗药物在微循环床的长时间接触。通过强化吉西他滨在组织中的灌注，获得了增强的抗肿瘤效果，且未伴随全身毒性的任何增加。在为胰腺供血的大血管选择性血管造影期间，肿瘤血管必须进行造影增强。1999年至2002年，对63例局部晚期肿瘤（T4NxMo）患者进行了诊断性血管造影。32例（51%）患者共进行了98次动脉内油性化疗栓塞（每位患者1 - 11次）。这些患者接受希罗达治疗后的1年和2年生存率分别为50%和15%。动脉油性化疗栓塞是一种治疗胰腺癌的安全且潜在有效的方法。
