Piekarska Anna, Zboińska Joanna, Szymczak Wiesław
Klinika Chorób Zakaźnych Uniwersytetu Medycznego w Łodzi.
Przegl Epidemiol. 2003;57(3):439-47.
Epidemiologic, etiologic and clinical assessment of patients with aseptic encephalomeningitis (AE); evaluation of efficacy of diagnostic process.
From January 1996 to August 2002, in seventy seven patients AE was diagnosed on the basis of lymphocytic predominance in cerebrospinal fluid (CSF) and negative culture of CSF. Analysis comprised: etiology, course of the disease and spectrum of used diagnostic tests.
In 48/77 patients (62.3%) etiology was not identified. In 8/77 patients (10.3%) herpes simplex encephalitis was diagnosed, in 7/77 (9.1%) neuroborreliosis, in 6/77 (7.8%) tuberculosis encephalitis, in 3/77 (3.9%) listerial meningitis, in 3/77 (3.9%) mumps meningitis, and in remaining 2/77 (2.6%) tick-borne encephalitis. The incidence of AE was higher in summer (42.9%) than in any other season. In 14/77 patients (18.2%) the episode of unconsciousness occurred in the course of the disease. In 6 of these 14 patient etiology was unknown, in 4 tuberculosis AE, in 2 herpes simplex encephalitis and in 2 neuroborreliosis was diagnosed. In 7 of 77 patients (9.0%) et least one episode of convulsions occurred.
In 62.3% of patients etiology remained unknown due to clinical and economic reasons. Aseptic encephalomeningitis in adults not always mean the viral etiology and mild course of the disease.
对无菌性脑膜炎（AE）患者进行流行病学、病因学及临床评估；评估诊断过程的有效性。
1996年1月至2002年8月，77例患者根据脑脊液（CSF）中淋巴细胞占优势且CSF培养阴性被诊断为AE。分析内容包括：病因、病程及所采用的诊断检查范围。
48/77例患者（62.3%）病因未明确。8/77例患者（10.3%）被诊断为单纯疱疹性脑炎，7/77例（9.1%）为神经莱姆病，6/77例（7.8%）为结核性脑炎，3/77例（3.9%）为李斯特菌脑膜炎，3/77例（3.9%）为腮腺炎脑膜炎，其余2/77例（2.6%）为蜱传脑炎。AE的发病率夏季较高（42.9%），高于其他任何季节。14/77例患者（18.2%）在病程中出现意识丧失。这14例患者中6例病因不明，4例为结核性AE，2例为单纯疱疹性脑炎，2例为神经莱姆病。77例患者中有7例（9.0%）至少发生过一次惊厥。
由于临床和经济原因，62.3%的患者病因仍不明确。成人无菌性脑膜炎并不总是意味着病毒病因及疾病的轻度病程。
