Pillon D J, Moree L, Rocha H, Pashley D H, Mendicino J, Leibach F H
Mol Cell Biochem. 1977 Dec 29;18(2-3):109-15. doi: 10.1007/BF00280276.
The effects of diamide were studied in rat kidney cortical tissue. It was found that diamide increased oxidized glutathione levels and inhibited Na+-K+-ATPase activity. Consistent with this finding was the observation that diamide compromised the sodium gradients maintained in renal cortical slices. Amino acid transport studies with ouabain or a sodium-free buffer indicated that diamide interferes with both Na+-dependent and Na+-independent transport systems. These results indicate that diamide has a number of different effects on renal cortical tissue and emphasize the important role of glutathione in maintaining control of a number of key metabolic pathways.
研究了二酰胺对大鼠肾皮质组织的影响。发现二酰胺可提高氧化型谷胱甘肽水平并抑制钠钾ATP酶活性。与这一发现一致的是，观察到二酰胺破坏了肾皮质切片中维持的钠梯度。用哇巴因或无钠缓冲液进行的氨基酸转运研究表明，二酰胺干扰了依赖钠和不依赖钠的转运系统。这些结果表明，二酰胺对肾皮质组织有多种不同影响，并强调了谷胱甘肽在维持对许多关键代谢途径的控制中的重要作用。
