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The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes.

作者信息

Thor H, Orrenius S

出版信息

Arch Toxicol. 1980 Mar;44(1-3):31-43. doi: 10.1007/BF00303181.

DOI:10.1007/BF00303181
PMID:7387401
Abstract
摘要

相似文献

1
The mechanism of bromobenzene-induced cytotoxicity studied with isolated hepatocytes.用分离的肝细胞研究溴苯诱导细胞毒性的机制。
Arch Toxicol. 1980 Mar;44(1-3):31-43. doi: 10.1007/BF00303181.
2
Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene.溴苯对培养肝细胞杀伤作用中的细胞损伤机制。
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3
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4
Early mitochondrial disfunction in bromobenzene treated mice: a possible factor of liver injury.
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Drug biotransformation and hepatotoxicity. Studies with bromobenzene in isolated hepatocytes.药物生物转化与肝毒性。溴苯在分离的肝细胞中的研究。
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6
Protective effects of aged garlic extract against bromobenzene toxicity to precision cut rat liver slices.aged大蒜提取物对溴苯对大鼠精密肝切片毒性的保护作用
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The role of 4-bromophenol and 4-bromocatechol in bromobenzene covalent binding and toxicity in isolated rat hepatocytes.
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Diffusion of reactive metabolites out of hepatocytes: studies with bromobenzene.
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Effects of cadmium on the energy metabolism of isolated hepatocytes: its relationship with the nonviability of isolated hepatocytes caused by cadmium.镉对分离的肝细胞能量代谢的影响：其与镉导致的分离肝细胞无活力的关系。
Biomed Environ Sci. 1990 Sep;3(3):251-61.
10
Toxicity and covalent binding of substituted bromobenzenes to isolated hepatocytes.取代溴苯对分离的肝细胞的毒性及共价结合
Adv Exp Med Biol. 1981;136 Pt A:381-6. doi: 10.1007/978-1-4757-0674-1_26.

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Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview.药物性肝毒性与草药抗氧化剂的预防：综述
Front Physiol. 2016 Jan 26;6:363. doi: 10.3389/fphys.2015.00363. eCollection 2015.
2
Isolated rat hepatocytes in suspension: potential hepatotoxic effects of six different drugs.悬浮状态下的分离大鼠肝细胞：六种不同药物的潜在肝毒性作用
Arch Toxicol. 1984 Nov;56(1):33-7. doi: 10.1007/BF00316349.
3
Acute cytotoxicities of polynuclear aromatic hydrocarbons determined in vitro with the human liver tumor cell line, HepG2.

本文引用的文献

1
ENZYME-STRUCTURE RELATIONSHIPS IN THE ENDOPLASMIC RETICULUM OF RAT LIVER : A Morphological and Biochemical Study.内质网中大鼠肝脏的酶结构关系：形态学和生物化学研究。
J Cell Biol. 1962 Dec 1;15(3):541-62. doi: 10.1083/jcb.15.3.541.
2
Enzyme-catalysed conjugations of glutathione with unsaturated compounds.谷胱甘肽与不饱和化合物的酶催化共轭反应。
Biochem J. 1967 Jul;104(1):95-102. doi: 10.1042/bj1040095.
3
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
用人肝癌细胞系HepG2体外测定多环芳烃的急性细胞毒性。
Cell Biol Toxicol. 1988 Sep;4(3):295-309. doi: 10.1007/BF00058738.
溴苯诱导的肝坏死。谷胱甘肽的保护作用及3,4-溴苯氧化物作为肝毒性代谢物的证据。
Pharmacology. 1974;11(3):151-69. doi: 10.1159/000136485.
4
A purified plasma membrane fraction isolated from rat liver under isotonic conditions.
Biochim Biophys Acta. 1967 Sep 9;135(4):573-9. doi: 10.1016/0005-2736(67)90089-2.
5
A study of drug metabolism linked to cytochrome P-450 in isolated rat-liver cells.
Eur J Biochem. 1974 Jul 15;46(2):351-60. doi: 10.1111/j.1432-1033.1974.tb03627.x.
6
Decrease in glutathione levels of kidney and liver after injection of methionine sulfoximine into rats.向大鼠注射蛋氨酸亚砜亚胺后肾脏和肝脏中谷胱甘肽水平的降低。
Biochem Biophys Res Commun. 1975 Feb 3;62(3):651-7. doi: 10.1016/0006-291x(75)90448-9.
7
Oxidative and conjugative metabolism of p-nitroanisole and p-nitrophenol in isolated rat liver cells.对硝基苯甲醚和对硝基苯酚在离体大鼠肝细胞中的氧化和结合代谢
Acta Pharmacol Toxicol (Copenh). 1976 Jul;39(1):17-32. doi: 10.1111/j.1600-0773.1976.tb03151.x.
8
The role of methionine in glutathione biosynthesis by isolated hepatocytes.蛋氨酸在分离的肝细胞谷胱甘肽生物合成中的作用。
Biochem Biophys Res Commun. 1977 Aug 22;77(4):1257-64. doi: 10.1016/s0006-291x(77)80115-0.
9
Metabolism of benzo(a)pyrene with isolated hepatocytes and the formation and degradation of DNA-binding derivatives.
J Biol Chem. 1977 Sep 25;252(18):6424-31.
10
Paracetamol metabolism and toxicity in isolated hepatocytes from rat and mouse.对乙酰氨基酚在大鼠和小鼠离体肝细胞中的代谢与毒性
Biochem Pharmacol. 1978;27(24):2859-63. doi: 10.1016/0006-2952(78)90201-0.