Abrahams John M, Gokhan Solen, Flamm Eugene S, Mehler Mark F
Department of Neurosurgery, Albert Einstein College of Medicine, New York, New York 10467, USA.
Neurosurgery. 2004 Jan;54(1):150-5; discussion 155-6. doi: 10.1227/01.neu.0000097515.27930.5e.
Recent studies documenting the phenomenon of de novo neurogenesis within the adult brain have propelled this area of research to the forefront of neuroscience investigations and stroke pathogenesis and treatment. Traditional theories have suggested that the central nervous system is incapable of neural regeneration; hence the emergence of the field of stem cell biology as a discipline devoted to uncovering novel forms of neural repair. However, several recent experimental observations have shown that the adult brain is capable of ongoing neurogenesis in discrete regions of the uninjured brain and additional forms of endogenous neural regeneration in the presence of an inciting event (induction neurogenesis). Induction neurogenesis has the potential for providing new insights into the cause and treatment of acute stroke syndromes.
最近有研究记录了成人大脑内新生神经发生的现象，这推动了该研究领域跃居神经科学研究以及中风发病机制与治疗研究的前沿。传统理论认为中枢神经系统无法进行神经再生；因此，干细胞生物学领域应运而生，成为一门致力于揭示新型神经修复形式的学科。然而，最近的一些实验观察表明，成人大脑在未受损脑区的离散区域能够持续进行神经发生，并且在有激发事件（诱导神经发生）的情况下还能进行其他形式的内源性神经再生。诱导神经发生有可能为急性中风综合征的病因和治疗提供新的见解。
