Discovery of a novel bicycloproline P2 bearing peptidyl alpha-ketoamide LY514962 as HCV protease inhibitor.
作者信息
Yip Yvonne, Victor Frantz, Lamar Jason, Johnson Robert, Wang Q May, Barket Donna, Glass John, Jin Ling, Liu Lifei, Venable Daryl, Wakulchik Mark, Xie Congping, Heinz Beverly, Villarreal Elcira, Colacino Joe, Yumibe Nathan, Tebbe Mark, Munroe John, Chen Shu-Hui
机构信息
Lilly Research Laboratory, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, IN 46285, USA.
出版信息
Bioorg Med Chem Lett. 2004 Jan 5;14(1):251-6. doi: 10.1016/j.bmcl.2003.09.074.
PMID:14684337
Abstract
We describe herein the design, syntheses and evaluation of a number of bicycloproline P2 bearing HCV protease inhibitors endowed with impressive enzyme potency, enzyme selectivity, cellular activity and favorable ADME profiles.
摘要
Zotero 插件