白细胞介素-6（IL6）基因型与男性的去脂体重相关，但与女性无关。
Interleukin-6 (IL6) genotype is associated with fat-free mass in men but not women.
作者信息
Roth Stephen M, Schrager Matthew A, Lee Mechele R, Metter E Jeffrey, Hurley Ben F, Ferrell Robert E
机构信息
Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2003 Dec;58(12):B1085-8. doi: 10.1093/gerona/58.12.b1085.
We studied the association of the G-174C promoter polymorphism in the interleukin-6 gene (IL6) with total body fat and fat-free mass (FFM) in 242 men and women (IL6 genotypes: G/G, n = 87; G/C, n = 100; C/C, n = 55) across the adult age span (21-92 years). In men, but not women (significant genotype by sex interactions; p =.023-.048), the C/C group exhibited significantly lower total FFM than the G/G group (54.7 +/- 0.8 kg vs 57.2 +/- 0.7 kg, respectively, p =.020), as well as significantly lower FFM of the lower limbs compared with the G/G group (18.4 +/- 0.3 kg vs 19.8 +/- 0.3 kg, respectively, p =.004). No significant genotype differences were observed in total body fat mass in either men or women. The results indicate that the IL6 G-174C polymorphism is significantly associated with FFM in men but not women.
我们研究了白细胞介素-6基因（IL6）中G-174C启动子多态性与242名成年男女（年龄范围21-92岁）的全身脂肪和去脂体重（FFM）之间的关联（IL6基因型：G/G，n = 87；G/C，n = 100；C/C，n = 55）。在男性中，而非女性中（基因型与性别存在显著交互作用；p = 0.023 - 0.048），C/C组的去脂体重总量显著低于G/G组（分别为54.7±0.8千克和57.2±0.7千克，p = 0.020），并且与G/G组相比，下肢去脂体重也显著更低（分别为18.4±0.3千克和19.8±0.3千克，p = 0.004）。在男性和女性的全身脂肪量方面均未观察到显著的基因型差异。结果表明，IL6 G-174C多态性与男性的去脂体重显著相关，而与女性无关。
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