Walsh Sean, Kelsey Bethany K, Angelopoulos Theodore J, Clarkson Priscilla M, Gordon Paul M, Moyna Niall M, Visich Paul S, Zoeller Robert F, Seip Richard L, Bilbie Steve, Thompson Paul D, Hoffman Eric P, Price Thomas B, Devaney Joseph M, Pescatello Linda S
Department of Kinesiology & Human Performance Laboratory, Neag School of Education, Univ. of Connecticut, Gampel Pavilion Rm. 206, 2095 Hillside Rd., U-1110, Storrs, CT 06269-1110, USA.
J Appl Physiol (1985). 2009 Oct;107(4):1235-40. doi: 10.1152/japplphysiol.90835.2008. Epub 2009 Jul 23.
The present study examined associations between the ciliary neurotrophic factor (CNTF) 1357 G --> A polymorphism and the muscle strength response to a unilateral, upper arm resistance-training (RT) program among healthy, young adults. Subjects were 754 Caucasian men (40%) and women (60%) who were genotyped and performed a training program of the nondominant (trained) arm with the dominant (untrained) arm as a comparison. Peak elbow flexor strength was measured with one repetition maximum, isometric strength with maximum voluntary contraction, and bicep cross-sectional area with MRI in the trained and untrained arms before and after training. Women with the CNTF GG genotype gained more absolute isometric strength, as measured by MVC (6.5 +/- 0.3 vs. 5.2 +/- 0.5 kg), than carriers of the CNTF A1357 allele in the trained arm pre- to posttraining (P < 0.05). No significant associations were seen in men. Women with the CNTF GG genotype gained more absolute dynamic (1.0 +/- 0.1 vs. 0.6 +/- 0.1 kg) and allometric (0.022 +/- 0.0 vs. 0.015 +/- 0.0 kg/kg(-0.67)) strength, as measured by 1 RM, than carriers of the CNTF A1357 allele in the untrained arm pre- to posttraining (P < 0.05). No significant associations were seen in men. No significant associations, as measured by cross-sectional area, were seen in men or women. The CNTF 1357 G --> A polymorphism explains only a small portion of the variability in the muscle strength response to training in women.
本研究调查了睫状神经营养因子（CNTF）1357 G→A多态性与健康年轻成年人单侧上臂抗阻训练（RT）计划的肌肉力量反应之间的关联。研究对象为754名白种人男性（40%）和女性（60%），他们接受了基因分型，并对非优势（训练）手臂进行了训练计划，以优势（未训练）手臂作为对照。在训练前后，通过一次重复最大值测量训练和未训练手臂的肘屈肌峰值力量，通过最大自主收缩测量等长力量，通过MRI测量肱二头肌横截面积。与训练前至训练后携带CNTF A1357等位基因的女性相比，携带CNTF GG基因型的女性在训练手臂中获得了更多的绝对等长力量，以最大自主收缩（MVC）衡量为（6.5±0.3 vs. 5.2±0.5 kg）（P<0.05）。在男性中未观察到显著关联。与训练前至训练后携带CNTF A1357等位基因的女性相比，携带CNTF GG基因型的女性在未训练手臂中获得了更多的绝对动态力量（1.0±0.1 vs. 0.6±0.1 kg）和异速生长力量（0.022±0.0 vs. 0.015±0.0 kg/kg(-0.67)），以一次重复最大值（1 RM）衡量（P<0.05）。在男性中未观察到显著关联。在男性或女性中，以横截面积衡量均未观察到显著关联。CNTF 1357 G→A多态性仅解释了女性训练肌肉力量反应变异性的一小部分。
