分泌状态以及对乳酸奈瑟菌和脑膜炎奈瑟菌的体液免疫反应。
Secretor status and humoral immune responses to Neisseria lactamica and Neisseria meningitidis.
作者信息
Zorgani A A, Stewart J, Blackwell C C, Elton R A, Weir D M
机构信息
Department of Medical Microbiology, Medical School, University of Edinburgh, Scotland.
出版信息
Epidemiol Infect. 1992 Dec;109(3):445-52. doi: 10.1017/s0950268800050433.
Non-secretors of ABO blood group antigens are over-represented among patients with meningococcal diseases. Lower levels of secretory IgA reported for non-secretors have been suggested to compromise mucosal defences. Total serum and salivary IgG, IgA and IgM and levels of these isotypes specific for Neisseria lactamica and five isolates of meningococci were determined by ELISA for 357 pupils and staff of a secondary school in which an outbreak of meningitis occurred. There were no differences in total or specific levels of serum IgG, IgA or IgM or salivary IgG or IgA of secretors compared with non-secretors. Non-secretors had significantly lower levels of salivary IgM (P = 0.022). A similar pattern was observed for levels of IgM specific for N. lactamica and five meningococcal isolates. The significance of these results is discussed with reference to the role of secretory IgM in protection of mucosal surfaces in infants.
ABO血型抗原非分泌者在脑膜炎球菌病患者中所占比例过高。据报道，非分泌者的分泌型IgA水平较低，这可能会损害黏膜防御功能。通过酶联免疫吸附测定法（ELISA），对一所发生脑膜炎暴发的中学的357名学生和教职员工，测定了血清和唾液中的总IgG、IgA和IgM，以及针对乳酸奈瑟菌和五株脑膜炎球菌分离株的这些同种型的水平。分泌者与非分泌者相比，血清IgG、IgA或IgM以及唾液IgG或IgA的总量或特异性水平没有差异。非分泌者的唾液IgM水平显著较低（P = 0.022）。对于乳酸奈瑟菌和五株脑膜炎球菌分离株特异性IgM的水平，也观察到了类似的模式。本文结合分泌型IgM在婴儿黏膜表面保护中的作用，对这些结果的意义进行了讨论。
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