有毒节肢动物的抗菌和细胞溶解肽。
Antimicrobial and cytolytic peptides of venomous arthropods.
作者信息
Kuhn-Nentwig L
机构信息
Zoological Institute, University of Bern, Baltzerstrasse 6, 3012 Bern, Switzerland.
出版信息
Cell Mol Life Sci. 2003 Dec;60(12):2651-68. doi: 10.1007/s00018-003-3106-8.
As a response to invading microorganisms, the innate immune system of arthropods has evolved a complex arrangement of constitutive and inducible antimicrobial peptides that immediately destroy a large variety of pathogens. At the same time, venomous arthropods have developed an additional offensive system in their venom glands to subdue their prey items. In this complex venom system, several enzymes, low-molecular-mass compounds, neurotoxins, antimicrobial and cytolytic peptides interact together, resulting in extremely rapid immobilization and/or killing of prey or aggressors. This review provides an overview of antimicrobial peptides identified in the hemolymph of venomous arthropods, and especially of cytolytic peptides in their venom. For these peptides a dual role is proposed: acting as antimicrobials as well as increasing the potency of the venom by influencing excitable cells.
作为对入侵微生物的一种反应，节肢动物的先天免疫系统已经进化出一套由组成型和诱导型抗菌肽构成的复杂组合，这些抗菌肽能立即摧毁多种病原体。与此同时，有毒节肢动物在其毒腺中还发展出了一种额外的攻击系统来制服猎物。在这个复杂的毒液系统中，几种酶、低分子量化合物、神经毒素、抗菌肽和细胞溶解肽相互作用，导致猎物或攻击者极其迅速地被 immobilization 和/或杀死。本综述概述了在有毒节肢动物血淋巴中鉴定出的抗菌肽，尤其是其毒液中的细胞溶解肽。对于这些肽，提出了一种双重作用：既作为抗菌剂，又通过影响可兴奋细胞来增强毒液的效力。 （注：immobilization 此处可能是“固定、使无法行动”之意，但原文拼写有误，推测可能是 immobilisation ）
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