Calboli Federico C F, Kennington W Jason, Partridge Linda
Department of Biology, University College London, Darwin Building, Gower Street, London, WC1E 2BT, United Kingdom.
Evolution. 2003 Nov;57(11):2653-8. doi: 10.1111/j.0014-3820.2003.tb01509.x.
Latitudinal genetic clines in body size are common in many ectotherm species and are attributed to climatic adaptation. Here, we use Quantitative Trait Loci (QTL) mapping to identify genomic regions associated with adaptive variation in body size in natural populations of Drosophila melanogaster from extreme ends of a cline in South America. Our results show that there is a significant association between the positions of QTL with strong effects on wing area in South America and those previously reported in a QTL mapping study of Australian cline end populations (P < 0.05). In both continents, the right arm of the third chromosome is associated with QTL with the strongest effect on wing area. We also show that QTL peaks for wing area and thorax length are associated with the same genomic regions, indicating that the clinal variation in the body size traits may have a similar genetic basis. The consistency of the results found for the South American and Australian cline end populations indicate that the genetic basis of the two clines may be similar and future efforts to identify the genes producing the response to selection should be focused on the genomic regions highlighted by the present work.
在许多变温动物物种中，体型的纬度遗传渐变很常见，这归因于气候适应。在这里，我们使用数量性状基因座（QTL）定位来确定与来自南美洲渐变极端两端的黑腹果蝇自然种群中体型适应性变异相关的基因组区域。我们的结果表明，在南美洲对翅面积有强烈影响的QTL位置与先前在澳大利亚渐变末端种群的QTL定位研究中报道的位置之间存在显著关联（P < 0.05）。在这两个大陆上，第三条染色体的右臂都与对翅面积影响最强的QTL相关。我们还表明，翅面积和胸长的QTL峰值与相同的基因组区域相关，这表明体型性状的渐变变异可能具有相似的遗传基础。在南美洲和澳大利亚渐变末端种群中发现的结果的一致性表明，这两个渐变的遗传基础可能相似，未来识别产生选择响应的基因的工作应集中在本研究突出的基因组区域上。
