Pashankar Dinesh S, Bishop Warren P, Loening-Baucke Vera
Division of Gastroenterology, Children's Hospital of Iowa, University of Iowa, Iowa City, Iowa 52242-1083, USA.
Clin Pediatr (Phila). 2003 Nov-Dec;42(9):815-9. doi: 10.1177/000992280304200907.
Seventy-four children (43 with chronic constipation, 31 with constipation and encopresis) treated with polyethylene glycol 3350 (PEG) for longer than 3 months were studied to assess long-term efficacy. The mean duration of PEG therapy was 8.4 months (range, 3-30). Weekly stool frequency, stool consistency, and symptoms associated with constipation improved significantly with PEG therapy in all 74 patients. In 31 children with encopresis, soiling ceased completely in 16 patients and frequency of soiling decreased significantly in all others. The average effective long-term dose of PEG was 0.7 g/kg/day. Long-term PEG therapy is effective for the treatment of chronic constipation with and without encopresis in children.
对74名接受聚乙二醇3350（PEG）治疗超过3个月的儿童（43名患有慢性便秘，31名患有便秘和大便失禁）进行了研究，以评估长期疗效。PEG治疗的平均持续时间为8.4个月（范围为3 - 30个月）。所有74名患者接受PEG治疗后，每周排便频率、大便稠度以及与便秘相关的症状均有显著改善。在31名大便失禁的儿童中，16名患者的污粪完全停止，其他所有患者的污粪频率均显著降低。PEG的长期平均有效剂量为0.7 g/kg/天。长期PEG治疗对治疗儿童伴有或不伴有大便失禁的慢性便秘有效。
