顺式-[Pt(NH₃)₂(L)]²⁺（L = Cl、H₂O、NH₃）与嘌呤和一氧化碳的结合：π反馈配位起作用吗？

cis-[Pt(NH3)2(L)]2+/+ (L = Cl, H2O, NH3) binding to purines and CO: does pi-back-donation play a role?

作者信息

Baik Mu-Hyun, Friesner Richard A, Lippard Stephen J

机构信息

Department of Chemistry and School of Informatics, Indiana University, Bloomington, Indiana 47405, USA.

出版信息

Inorg Chem. 2003 Dec 29;42(26):8615-7. doi: 10.1021/ic035022b.

DOI:10.1021/ic035022b

PMID:14686835

Abstract

The ability of cis-Pt(NH(3))(2)(L), a molecular fragment of the anticancer drug cisplatin, to bind to purines and CO by pi-back-donation from Pt to the ligand was examined computationally. Optimized geometries and computed vibrational frequencies suggest that cis-Pt(NH(3))(2)(L) (L = Cl, H(2)O, NH(3)) is a poor pi-donor and that pi-back-donation does not play an important role for Pt(II)-ligand interactions in general.

摘要

对顺铂（一种抗癌药物）的分子片段顺式-[Pt(NH₃)₂(L)]²⁺/⁺通过从铂到配体的π-反馈配位作用与嘌呤和一氧化碳结合的能力进行了计算研究。优化的几何结构和计算出的振动频率表明，顺式-[Pt(NH₃)₂(L)]²⁺/⁺（L = Cl、H₂O、NH₃）是一种较差的π-供体，并且一般来说，π-反馈配位在Pt(II)-配体相互作用中并不起重要作用。