Bernard J D, Rimailho J, Pourrut J C, Hoff J, Becue J
Service de Chirurgie Générale et Gynécologique, Hôpital Rangueil, Toulouse, France.
Gynecol Oncol. 1992 Nov;47(2):255-9. doi: 10.1016/0090-8258(92)90116-z.
A premenopausal woman developed hypercalcemia 30 months after treatment for infiltrating breast cancer. After bone metastases had been excluded, primary hyperparathyroidism was suspected. A parathyroid adenoma was removed and histologically confirmed. Hypercalcemia, associated with low plasma phosphate and severely depressed plasma parathormone (PTH) levels, persisted. Further investigations showed liver metastases from the primary breast cancer and also secretion of a PTH-like substance. Antitumoral treatment was effective on the liver metastases and also normalized calcemia and the PTH-like substance, demonstrating the existence of a paraneoplastic syndrome related to the secretion of a PTH-like substance by disseminated liver metastases of primary breast cancer.
一名绝经前女性在浸润性乳腺癌治疗30个月后出现高钙血症。排除骨转移后，怀疑为原发性甲状旁腺功能亢进。切除甲状旁腺腺瘤并经组织学证实。高钙血症持续存在，伴有血浆磷酸盐水平降低和血浆甲状旁腺激素（PTH）水平严重降低。进一步检查显示原发性乳腺癌有肝转移，且还分泌一种PTH样物质。抗肿瘤治疗对肝转移有效，血钙和PTH样物质也恢复正常，证明存在一种与原发性乳腺癌肝转移灶分泌PTH样物质相关的副肿瘤综合征。
