Arps H, Dietel M, Schulz A, Janzarik H, Klöppel G
Virchows Arch A Pathol Anat Histopathol. 1986;408(5):497-503. doi: 10.1007/BF00705303.
In a case of pancreatic endocrine carcinoma hypercalcaemia without bone metastases and normal parathyroid glands prompted our suspicion that there was paraneoplastic production of an osteoclast activating substance by the tumour tissue. This view was further confirmed by bone histology. Immunohistology post mortem revealed the production of PTH in the primary tumour and a liver metastasis. The usefulness of immunohistology in detecting paraneoplastic secretion of hormonal substances is discussed.
在一例胰腺内分泌癌患者中，无骨转移且甲状旁腺正常却出现高钙血症，这促使我们怀疑肿瘤组织产生了一种破骨细胞激活物质，从而引发了副肿瘤综合征。骨组织学进一步证实了这一观点。尸检免疫组织学显示，原发性肿瘤及肝转移灶中均有甲状旁腺激素产生。本文讨论了免疫组织学在检测激素物质副肿瘤分泌方面的作用。
