Hayakawa Yoshihiro, Screpanti Valentina, Yagita Hideo, Grandien Alf, Ljunggren Hans-Gustaf, Smyth Mark J, Chambers Benedict J
Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
J Immunol. 2004 Jan 1;172(1):123-9. doi: 10.4049/jimmunol.172.1.123.
Recent studies have implicated a possible role for NK cells in regulating dendritic cells (DC) in vitro. In the present study, we demonstrate that immature DC are rapidly eliminated by NK cells in vivo via a pathway dependent on the TNF-related apoptosis-inducing ligand (TRAIL). Elimination of NK cells and/or neutralization of TRAIL function during immunization with immature DC loaded with nonself or tumor Ags significantly enhanced T cell responses to these Ags and Ag-specific tumor immunity. These data suggested that NK cell TRAIL might regulate responses to vaccination by controlling the survival of Ag-loaded DC.
近期研究表明，自然杀伤细胞（NK细胞）在体外调节树突状细胞（DC）方面可能发挥作用。在本研究中，我们证明未成熟DC在体内会通过依赖肿瘤坏死因子相关凋亡诱导配体（TRAIL）的途径被NK细胞迅速清除。在用负载非自身或肿瘤抗原的未成熟DC进行免疫接种期间，清除NK细胞和/或中和TRAIL功能可显著增强T细胞对这些抗原的反应以及抗原特异性肿瘤免疫。这些数据表明，NK细胞TRAIL可能通过控制负载抗原的DC的存活来调节对疫苗接种的反应。
