Bilgic Bilge, Mete Ozgür, Oztürk Settar A, Demiryont Misten, Keles Nesil, Basaran Mert
Department of Pathology, Istanbul Medical Faculty, 34390 Istanbul, Turkey.
Pathol Oncol Res. 2003;9(4):242-5. doi: 10.1007/BF02893385. Epub 2003 Dec 22.
Synovial sarcoma is a soft tissue sarcoma of unknown histogenesis and occurs predominantly in the lower extremities of young adults. The head and neck is a relative rare location. There are about 10 cases with laryngeal localization in the literature. We present a 24 year-old male with an endolaryngeal mass. Incisional biopsy and the hemilaryngectomy material revealed a biphasic synovial sarcoma. One year later a local recurrence occurred. Tumor excision and neck dissection were performed. Radiotherapy was added. Six months later lung metastases was discovered on thoracic CT. The patient received chemotherapy for 6 courses. The metastases responded well to chemotherapy and the patient is now alive without tumor on radiological and clinical examination after 3.5 years of follow-up.
滑膜肉瘤是一种组织发生不明的软组织肉瘤,主要发生于年轻成年人的下肢。头颈部是相对少见的发病部位。文献中约有10例喉部滑膜肉瘤的报道。我们报告1例24岁男性患者,其喉部有一肿物。切开活检及半喉切除标本显示为双相型滑膜肉瘤。1年后出现局部复发,遂行肿瘤切除及颈部淋巴结清扫术,并加用放疗。6个月后胸部CT发现肺转移。患者接受了6个疗程的化疗。转移灶对化疗反应良好,随访3.5年后,经影像学和临床检查,患者目前存活且无肿瘤复发。