Quan Hongzhi, Sreekissoon Senjeet, Wang Yan
Department of Oral Maxillofacial Surgery, Xiangya Stomatological Hospital and School of Stomatology, Central South University, Changsha, Hunan, China.
School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China.
Front Cell Dev Biol. 2023 Jan 6;10:1077756. doi: 10.3389/fcell.2022.1077756. eCollection 2022.
Synovial sarcoma (SS) is a high-grade soft-tissue sarcoma that occurs predominantly in older children and young adults in their thirties. It is usually very challenging to diagnose and treat synovial sarcoma in the head and neck region. The purpose of this review is to investigate the clinical manifestations and different treatment methods in the management of primary synovial sarcoma of the head and neck. HNSS has an aggressive nature and poor prognosis. Surgical resection, radiotherapy, and chemotherapy are the primary treatment methods. Typically, surgical resection with negative margins remains the foundation of therapy, which is not very easily achieved in the head and neck due to its complex anatomical structure and the presence of many blood vessels and nerves. However, synovial sarcoma has a high recurrence rate, so aggressive management and close follow-up are warranted for the optimal outcome.
滑膜肉瘤（SS）是一种高级别软组织肉瘤，主要发生于大龄儿童和30岁左右的年轻人。对头颈部滑膜肉瘤进行诊断和治疗通常极具挑战性。本综述的目的是研究头颈部原发性滑膜肉瘤的临床表现及不同治疗方法。头颈部滑膜肉瘤具有侵袭性，预后较差。手术切除、放疗和化疗是主要治疗方法。通常，切缘阴性的手术切除仍是治疗的基础，但由于头颈部解剖结构复杂，血管和神经众多，在该部位实现这一点并非易事。然而，滑膜肉瘤复发率高，因此为获得最佳疗效，积极治疗和密切随访是必要的。
