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Cochinmicins, novel and potent cyclodepsipeptide endothelin antagonists from a Microbispora sp. I. Production, isolation, and characterization.

作者信息

Lam Y K, Williams D L, Sigmund J M, Sanchez M, Genilloud O, Kong Y L, Stevens-Miles S, Huang L, Garrity G M

机构信息

Merck Research Laboratories, Rahway, New Jersey 07065.

出版信息

J Antibiot (Tokyo). 1992 Nov;45(11):1709-16. doi: 10.7164/antibiotics.45.1709.

DOI:10.7164/antibiotics.45.1709
PMID:1468977
Abstract

Cochinmicins I, II, III are novel peptolides produced in submerged-fermentation cultures of Microbispora sp. ATCC 55140. These closely related compounds are separated by HPLC and are novel competitive endothelin antagonists. Cochinmicins II and III are stereoisomeric to each other. Cochinmicin I is the deschloro analog of cochinmicin III.

摘要

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