RES-701-2、-3和-4，由链霉菌属产生的新型选择性内皮素B型受体拮抗剂。I. 产生菌的分类学、发酵、分离及生化特性
RES-701-2, -3 and -4, novel and selective endothelin type B receptor antagonists produced by Streptomyces sp. I. Taxonomy of producing strains, fermentation, isolation, and biochemical properties.
作者信息
Ogawa T, Ochiai K, Tanaka T, Tsukuda E, Chiba S, Yano K, Yamasaki M, Yoshida M, Matsuda Y
机构信息
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd. Japan.
出版信息
J Antibiot (Tokyo). 1995 Nov;48(11):1213-20. doi: 10.7164/antibiotics.48.1213.
RES-701-2, -3 and -4, novel cyclic peptide endothelin antagonists, were isolated from the culture broths of Streptomyces sp. RE-701 and RE-896, RES-701s selectively inhibited the ET-1 binding to endothelin type B receptor (ETB receptor) with IC50 values ranging from 5 to 20 nM. Taxonomy of the producing strains, fermentation, isolation and biochemical properties of RES-701s are described.
RES-701-2、-3和-4是新型环肽内皮素拮抗剂，从链霉菌属RE-701和RE-896的培养液中分离得到。RES-701s选择性抑制内皮素-1与B型内皮素受体（ETB受体）的结合，IC50值在5至20 nM之间。本文描述了产生菌的分类学、RES-701s的发酵、分离及生化特性。
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