Spencer Tim, Filbin Marie T
Department of Biological Sciences, Hunter College, The City University of New York, NY 10021, USA.
J Anat. 2004 Jan;204(1):49-55. doi: 10.1111/j.1469-7580.2004.00259.x.
Injury to the adult mammalian central nervous system (CNS) often results in permanent loss of sensory and motor function. This is due to the failure of injured axons to regenerate. The inhibitory nature of the CNS can be attributed to several factors, including formation of the glial scar, the presence of several molecules, associated with myelin, which inhibit axonal regrowth, and the intrinsic growth state of these neurons. Encouraging regeneration in the adult mammalian CNS therefore will require targeting one or all of these factors following injury. Here we illustrate recent work from our laboratory that identifies some of the signalling components involved in modulation of the intrinsic growth state of adult neurons. When activated, these signalling pathways can induce axonal regeneration in the presence of the myelin-associated inhibitors both in vitro and in vivo.
成年哺乳动物中枢神经系统（CNS）损伤常导致感觉和运动功能的永久性丧失。这是由于受损轴突无法再生所致。中枢神经系统的抑制特性可归因于多种因素，包括胶质瘢痕的形成、与髓磷脂相关的几种抑制轴突再生的分子的存在，以及这些神经元的内在生长状态。因此，促进成年哺乳动物中枢神经系统的再生将需要在损伤后针对这些因素中的一个或全部。在这里，我们阐述了我们实验室最近的工作，该工作确定了一些参与调节成年神经元内在生长状态的信号成分。当被激活时，这些信号通路能够在体外和体内存在髓磷脂相关抑制剂的情况下诱导轴突再生。
