Vibert Laura, Daulny Anne, Jarriault Sophie
Department of Development and Stem Cells, IGBMC (Institut de Génétique et de Biologie Moléculaire et Cellulaire), CNRS UMR 7104/INSERM U1258, Université de Strasbourg, Strasbourg, France.
Int J Dev Biol. 2018;62(6-7-8):491-505. doi: 10.1387/ijdb.180123sj.
Regeneration and wound healing are complex processes that allow organs and tissues to regain their integrity and functionality after injury. Wound healing, a key property of epithelia, involves tissue closure that in some cases leads to scar formation. Regeneration, a process rather limited in mammals, is the capacity to regrow (parts of) an organ or a tissue, after damage or amputation. What are the properties of organs and the features of tissue permitting functional regrowth and repair? What are the cellular and molecular mechanisms underlying these processes? These questions are crucial both in fundamental and applied contexts, with important medical implications. The mechanisms and cells underlying tissue repair have thus been the focus of intense investigation. The last decades have seen rapid progress in the domain and new models emerging. Here, we review the fundamental advances and the perspectives that the use of C. elegans as a model have brought to the mechanisms of wound healing and cellular plasticity, axon regeneration and transdifferentiation in vivo.
再生和伤口愈合是复杂的过程，使器官和组织在受伤后恢复其完整性和功能。伤口愈合是上皮细胞的一个关键特性，涉及组织闭合，在某些情况下会导致疤痕形成。再生在哺乳动物中是一个相当有限的过程，是指器官或组织在受损或截肢后重新生长（部分）的能力。允许功能再生和修复的器官特性和组织特征是什么？这些过程背后的细胞和分子机制是什么？这些问题在基础和应用背景下都至关重要，具有重要的医学意义。因此，组织修复的机制和细胞一直是深入研究的焦点。在过去几十年里，该领域取得了迅速进展，新的模型不断涌现。在这里，我们回顾了以秀丽隐杆线虫为模型在伤口愈合和细胞可塑性、轴突再生以及体内转分化机制方面所取得的基本进展和前景。
