Kassis E
Scand J Respir Dis. 1977 Dec;58(6):324-9.
Left ventricular function was evaluated prospectively during 1 year in a controlled clinical study of 73 patients with chronic obstructive lung disease. The control group comprised 68 patients matched for age and sex and with no evidence of airways obstruction. Left ventricular hypertrophy was found in 52% and systemic hypertension in 58% of patients in the study group compared with 6% and 15% respectively in the controls. Left ventricular hypertrophy was diagnosed in 70% of patients with chronic bronchitis and in 19% of those with chronic emphysema. Systemic hypertension was observed in 45% of the bronchitic type patients and in 81% of those with emphysema. The incidence of myocardial infarction in the study group was not lower than in the controls. The high frequency of left ventricular hypertrophy in patients with chronic obstructive lung disease can probably be related to a similar high frequency of systemic hypertension. Hypertension per se does not explain left ventricular hypertrophy in all patients with chronic bronchitis, but hypoxemia and acidosis seem to be of pathogenetic importance in these cases.
在一项对73例慢性阻塞性肺疾病患者进行的为期1年的对照临床研究中，对左心室功能进行了前瞻性评估。对照组由68例年龄和性别匹配且无气道阻塞证据的患者组成。研究组中52%的患者出现左心室肥厚，58%的患者出现系统性高血压，而对照组中这两个比例分别为6%和15%。慢性支气管炎患者中70%被诊断为左心室肥厚，慢性肺气肿患者中19%被诊断为左心室肥厚。支气管炎型患者中45%出现系统性高血压，肺气肿患者中81%出现系统性高血压。研究组中心肌梗死的发生率不低于对照组。慢性阻塞性肺疾病患者左心室肥厚的高发生率可能与系统性高血压的相似高发生率有关。高血压本身并不能解释所有慢性支气管炎患者的左心室肥厚，但低氧血症和酸中毒在这些病例中似乎具有致病重要性。
