Orford M R, Leung F C, Milligan G, Saggerson E D
Department of Biochemistry and Molecular Biology, University College London, UK.
J Neurol Sci. 1992 Oct;112(1-2):34-7. doi: 10.1016/0022-510x(92)90128-8.
Treatment of rats for 3 days with T3 halved the abundance of the alpha-subunits of Gi1 and Gi2 in synaptosomal membranes isolated from the cerebral cortex. It is suggested that these changes could contribute to behavioural abnormalities in hyperthyroidism. Similar T3 treatment did not alter abundance of Gi1 alpha or Gi2 alpha in the medulla oblongata nor did it alter abundance of G(o) alpha-subunits in three tested brain regions.
用T3对大鼠进行为期3天的治疗，使从大脑皮层分离出的突触体膜中Gi1和Gi2的α亚基丰度减半。有人认为，这些变化可能导致甲状腺功能亢进时的行为异常。类似的T3治疗并未改变延髓中Gi1α或Gi2α的丰度，也未改变三个测试脑区中G(o)α亚基的丰度。
