从菲律宾海绵黑皮海绵中分离得到的新型细胞毒性甾体生物碱。

New cytotoxic steroidal alkaloids from the Philippine sponge Corticium niger.

作者信息

Ridley Christian P, Faulkner D John

机构信息

Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093-0212F, USA

出版信息

J Nat Prod. 2003 Dec;66(12):1536-9. doi: 10.1021/np0302706.

DOI:10.1021/np0302706

PMID:14695791

Abstract

Four new steroidal alkaloids, plakinamine I-K (1-3) and dihydroplakinamine K (4), were isolated from the marine sponge Corticium niger. The structures of these compounds were elucidated by interpretation of spectroscopic data. Compounds 1-4 exhibit significant in vitro cytotoxicity.

摘要

从海洋海绵黑皮质海绵中分离出四种新的甾体生物碱，普拉基胺I-K（1-3）和二氢普拉基胺K（4）。通过光谱数据分析阐明了这些化合物的结构。化合物1-4表现出显著的体外细胞毒性。