瑞尼霉素J，一种具有高度细胞毒性的四氢异喹啉生物碱，源自海洋海绵新岩海绵属物种。
Renieramycin J, a highly cytotoxic tetrahydroisoquinoline alkaloid, from a marine sponge Neopetrosia sp.
作者信息
Oku Naoya, Matsunaga Shigeki, van Soest Rob W M, Fusetani Nobuhiro
机构信息
Laboratory of Aquatic Natural Products Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Bunkyo-ku, Tokyo 113-8657, Japan.
出版信息
J Nat Prod. 2003 Aug;66(8):1136-9. doi: 10.1021/np030092g.
Renieramycin J (1), a new tetrahydroisoquinoline alkaloid, has been isolated from a marine sponge Neopetrosia sp. as a potent cytotoxin that induced morphological changes in 3Y1 cells. Such changes are characteristic of RNA and/or protein synthesis inhibitors. The structure of 1 including the absolute stereochemistry was determined by spectroscopic and chemical methods.
雷尼霉素J（1）是一种新的四氢异喹啉生物碱，从海洋海绵新岩海绵属（Neopetrosia sp.）中分离得到，是一种强效细胞毒素，可诱导3Y1细胞发生形态变化。这些变化是RNA和/或蛋白质合成抑制剂的特征。通过光谱和化学方法确定了1的结构，包括绝对立体化学。
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