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天然甾体生物碱的化学性质与生物活性

Chemistry and bioactivities of natural steroidal alkaloids.

作者信息

Xiang Mei-Ling, Hu Bin-Yuan, Qi Zi-Heng, Wang Xiao-Na, Xie Tian-Zhen, Wang Zhao-Jie, Ma Dan-Yu, Zeng Qi, Luo Xiao-Dong

机构信息

Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, Yunnan Provincial Center for Research & Development of Natural Products, School of Chemical Science and Technology, Yunnan University, Kunming, 650091, People's Republic of China.

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.

出版信息

Nat Prod Bioprospect. 2022 Jun 15;12(1):23. doi: 10.1007/s13659-022-00345-0.

DOI:10.1007/s13659-022-00345-0
PMID:35701630
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9198197/
Abstract

Steroidal alkaloids possess the basic steroidal skeleton with a nitrogen atom in rings or side chains incorporated as an integral part of the molecule. They have demonstrated a wide range of biological activities, and some of them have even been developed as therapeutic drugs, such as abiraterone acetate (Zytiga), a blockbuster drug, which has been used for the treatment of prostate cancer. Structurally diverse natural steroidal alkaloids present a wide spectrum of biological activities, which are attractive for natural product chemistry and medicinal chemistry communities. This review comprehensively covers the structural classification, isolation and various biological activities of 697 natural steroidal alkaloids discovered from 1926 to October 2021, with 363 references being cited.

摘要

甾体生物碱具有基本的甾体骨架，环或侧链中的氮原子作为分子的一个组成部分并入其中。它们已显示出广泛的生物活性，其中一些甚至已被开发为治疗药物，例如重磅炸弹药物醋酸阿比特龙（泽珂），已用于治疗前列腺癌。结构多样的天然甾体生物碱呈现出广泛的生物活性，这对天然产物化学和药物化学领域具有吸引力。本综述全面涵盖了1926年至2021年10月发现的697种天然甾体生物碱的结构分类、分离及各种生物活性，并引用了363篇参考文献。

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