Graham Peter, Browne Lois, Capp Anne, Fox Christopher, Graham Jennifer, Hollis Julie, Nasser Elias
Cancer Care Centre, St. George Hospital, University of New South Wales, Kogarah, New South Wales, Australia.
Int J Radiat Oncol Biol Phys. 2004 Jan 1;58(1):241-6. doi: 10.1016/s0360-3016(03)01431-7.
Postmastectomy irradiation provides an excellent model for irradiated skin care practices because of the relatively uniform surface and radiation compared with other situations in which radiation-induced moist desquamation is common. We designed a study to test the effect of prophylactic 3M Cavilon No-Sting Barrier Film (No-Sting) on the rates of moist desquamation compared with sorbolene cream (with 10% glycerin).
The irradiated chest wall was divided into medial and lateral halves. Sixty-one women were randomized to have No-Sting applied to either the medial or lateral half, with the alternate half treated with sorbolene.
For all patients, the skin toxicity, calculated as the area under the curve, mean No-Sting and sorbolene score was 8.1 vs. 9.2, respectively (p = 0.005, Wilcoxon signed rank test). The total number of weeks of moist desquamation for the 61 patients was 40 vs. 45, equating to a mean of 0.65 week vs. 0.74 week per patient in the No-Sting and sorbolene-treated areas, respectively. The rates of moist desquamation were 33% vs. 46% (p = 0.096, McNemar's Exact test). For 58 fully assessable patients (minimum of 7 weekly observations), the area under the curve and rates of moist desquamation were significantly different statistically (p = 0.002 and 0.049, respectively). No statistically significant differences were noted in the pain scores. The pruritus scores were significantly reduced in the No-Sting area (area under the curve, p = 0.011).
No-Sting reduces the duration and frequency of radiation-induced moist desquamation.
乳房切除术后放疗为放射性皮肤护理实践提供了一个极佳的模型，因为与放射性湿性脱皮常见的其他情况相比，其表面和辐射相对均匀。我们设计了一项研究，以测试预防性使用3M Cavilon无刺痛屏障膜（无刺痛）与索布伦乳膏（含10%甘油）相比对湿性脱皮发生率的影响。
将接受放疗的胸壁分为内侧和外侧两半。61名女性被随机分配，在内侧或外侧半侧涂抹无刺痛，另一侧涂抹索布伦。
对于所有患者，以曲线下面积计算的皮肤毒性，无刺痛和索布伦的平均评分分别为8.1和9.2（p = 0.005，Wilcoxon符号秩检验）。61名患者的湿性脱皮总周数分别为40周和45周，相当于无刺痛治疗区域和索布伦治疗区域每位患者平均分别为0.65周和0.74周。湿性脱皮发生率分别为33%和46%（p = 0.096，McNemar精确检验）。对于58名可完全评估的患者（至少每周观察7次），曲线下面积和湿性脱皮发生率在统计学上有显著差异（分别为p = 0.002和0.049）。疼痛评分无统计学显著差异。无刺痛区域的瘙痒评分显著降低（曲线下面积，p = 0.011）。
无刺痛可减少放射性湿性脱皮的持续时间和频率。
