Wang Y-l, Tang Z-q, Gao W, Jiang Y, Zhang X-h, Peng L
Tianjin Institute of Thrombosis and Hemostasis, Organ Transplantation Center of Tianjin, First Central Hospital, 24 Fukang Road, Tianjin 300-192, P.R. China.
Transplant Proc. 2003 Dec;35(8):3024-5. doi: 10.1016/j.transproceed.2003.10.007.
To investigate the change of Th1, Th2, Th3 cytokines during early liver transplantation. IFN-r, IL-4, TGF-beta production by CD4+ T cells were determined by fluorescence activated cell sorter analysis. Comparing the acute rejection with the non-acute rejection groups on the 7th, 14th, and 28th day showed that high interferon-gamma production associated with acute rejection in the early posttransplant period. There was no evidence of significant changes in interleukin-4 and transforming growth factor beta (TGF-beta) levels between non-acute rejection groups with acute rejection groups. Th1 cytokine high production is significantly associated with acute rejection in liver transplant recipients.
为研究肝移植早期Th1、Th2、Th3细胞因子的变化。通过荧光激活细胞分选分析测定CD4+T细胞产生的IFN-γ、IL-4、TGF-β。比较急性排斥组与非急性排斥组在第7天、第14天和第28天的情况，结果显示移植后早期急性排斥与高干扰素-γ产生相关。急性排斥组与非急性排斥组之间白细胞介素-4和转化生长因子β（TGF-β）水平无显著变化。肝移植受者中Th1细胞因子高产生与急性排斥显著相关。
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