Arikan C, Kilic M, Tokat Y, Aydogdu S
Department of Pediatric Gastroenterology, Hepatology and Nutrition, Ege University Organ Transplant and Research Center, 250 sok. Mustafa Cukur Sitesi B1 Blk., No: 6 D:1, 35500 Izmir, Turkey.
Transplant Proc. 2003 Dec;35(8):3039-41. doi: 10.1016/j.transproceed.2003.10.033.
Cyclosporine A (CsA) and tacrolimus (Tac), both calcineurin inhibitors, have been used extensively for immunosuppressive therapy in pediatric liver transplant recipients. They share a similar mechanism of action, the inhibition of cytokine gene transcription primarily interleukin-2 (IL-2) in T lymphocytes. Despite the strong immunosuppressive property, there are several reports of food allergy in pediatric transplant recipients under Tac immunosuppression, but not CsA. In this paper we report on 3 of 50 pediatric liver transplant recipients diagnosed with food allergy and asthma while receiving systemic Tac/CsA immunosuppression and the discuss the role of calcineurin inhibitors in this situation.
环孢素A（CsA）和他克莫司（Tac）均为钙调神经磷酸酶抑制剂，已广泛用于小儿肝移植受者的免疫抑制治疗。它们具有相似的作用机制，即主要抑制T淋巴细胞中细胞因子基因转录，尤其是白细胞介素-2（IL-2）。尽管具有强大的免疫抑制特性，但有几份报告称，接受Tac免疫抑制的小儿移植受者出现食物过敏，而接受CsA免疫抑制的则未出现。在本文中，我们报告了50例接受全身性Tac/CsA免疫抑制治疗的小儿肝移植受者中有3例被诊断为食物过敏和哮喘，并讨论了钙调神经磷酸酶抑制剂在这种情况下的作用。
