Machura Edyta, Chodór Beata, Kleszyk Magdalena, Pindycka-Piaszczyńska Małgorzata, Chrobak Ewelina, Białkowski Jacek
Department of Pediatrics, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Independent Public Clinical Hospital No. 1 in Zabrze, Poland.
Department of Cardiology, Congenital Heart Diseases, and Electrotherapy with the Division of Pediatric Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Silesian Center for Heart Diseases, Zabrze, Poland.
Kardiochir Torakochirurgia Pol. 2015 Jun;12(2):176-80. doi: 10.5114/kitp.2015.52866. Epub 2015 Jun 30.
In recent years, we have been observing an increased proportion of atopic diseases in children after solid organ transplantation. The pathogenesis of post-transplantation allergy is not completely understood and probably involves several factors, including immunosuppressive therapy. In this paper we present a case of 3-year old boy, after orthotopic heart transplantation at 6 months of age, with symptoms of food allergy associated with atopic dermatitis and changes in the orofacial area. The mentioned symptoms and elevated levels of total and specific IgE occurred with a year of transplant. Because of failure to achieve remission after typical allergy therapy we suspected that the reason of allergy in this case can be immunosuppressive therapy.
近年来，我们观察到实体器官移植后儿童特应性疾病的比例有所增加。移植后过敏的发病机制尚未完全明确，可能涉及多种因素，包括免疫抑制治疗。本文介绍了一名3岁男孩的病例，该男孩在6个月大时接受了原位心脏移植，出现了与特应性皮炎相关的食物过敏症状以及口面部区域的变化。上述症状以及总IgE和特异性IgE水平升高在移植后一年出现。由于典型过敏治疗后未能实现缓解，我们怀疑该病例中过敏的原因可能是免疫抑制治疗。
