在无猫冷冻试验装置上，导水管周围灰质（PAG）的不同区域参与了带帽PVG大鼠的冷冻行为。
Distinct regions of periaqueductal gray (PAG) are involved in freezing behavior in hooded PVG rats on the cat-freezing test apparatus.
作者信息
Farook J M, Wang Q, Moochhala S M, Zhu Z Y, Lee L, Wong P T-H
机构信息
Department of Pharmacology, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA.
出版信息
Neurosci Lett. 2004 Jan 9;354(2):139-42. doi: 10.1016/j.neulet.2003.10.011.
The periaqueductal gray (PAG) is considered to be an exit relay for defensive responses. Studies have shown that the ventrolateral periaqueductal gray (vlPAG) plays a role in the expression of freezing behavior whereas dorsolateral periaqueductal gray (dlPAG) is involved on both freezing and active forms of defensive behaviors. To further elucidate this theory, lesioned vlPAG and dlPAG rats were exposed to a cat in the cat-freezing test apparatus. Subsequently, a 7-day repeated exposure to a cat was done on the vlPAG and dlPAG lesioned rats. Results showed that the vlPAG lesioned rats demonstrated significant decrease in freezing behavior and corresponding increase in locomotor activity, while the dlPAG lesioned rats failed to show any significance. Subsequent repeated exposure of the vlPAG lesioned rats to a cat for 7 days showed a gradual decrease in freezing behavior with significance shown at days 5, 6 and 7 while the dlPAG lesioned rats failed to show any changes. These results suggest that vlPAG regulates freezing behavior in hooded PVG rats.
导水管周围灰质（PAG）被认为是防御反应的一个传出中继站。研究表明，腹外侧导水管周围灰质（vlPAG）在僵住行为的表现中起作用，而背外侧导水管周围灰质（dlPAG）则参与僵住行为和主动防御行为。为了进一步阐明这一理论，在无猫的测试装置中，将损毁vlPAG和dlPAG的大鼠暴露于猫面前。随后，对损毁vlPAG和dlPAG的大鼠进行为期7天的重复猫暴露实验。结果显示，损毁vlPAG的大鼠僵住行为显著减少，运动活动相应增加，而损毁dlPAG的大鼠则未表现出任何显著变化。随后对损毁vlPAG的大鼠进行为期7天的重复猫暴露实验，结果显示僵住行为逐渐减少，在第5、6和7天表现出显著性，而损毁dlPAG的大鼠未表现出任何变化。这些结果表明，vlPAG调节带帽PVG大鼠的僵住行为。
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