Muellenhoff Matthew, Cukrowski Tiffany, Morgan Michael, Dorton David
Department of Dermatology, Odessa, FL, USA.
J Am Acad Dermatol. 2004 Jan;50(1):136-9. doi: 10.1016/s0190-9622(03)00407-9.
Pemphigus vulgaris is an autoimmune blistering disorder of the skin and mucous membranes. Numerous medications, ultraviolet light, and radiation have all been implicated in the etiology of the disease. We present a patient with pemphigus vulgaris whose disease developed after administration of anthrax vaccine. The histologic and immunofluorescence findings were characteristic of pemphigus vulgaris. Adverse systemic events associated with the anthrax vaccine consist primarily of flu-like symptoms. Previous cases of pemphigus vulgaris associated with anthrax vaccine administration have not been reported. Considering the recent deliberate outbreaks of anthrax and continued threats of bioterrorism, the potential exists for widespread administration of the anthrax vaccine. Accordingly, continued observation and documentation of true adverse events is needed.
寻常型天疱疮是一种皮肤和黏膜的自身免疫性水疱性疾病。多种药物、紫外线及辐射均与该病的病因有关。我们报告一例寻常型天疱疮患者，其疾病在接种炭疽疫苗后发生。组织学和免疫荧光检查结果符合寻常型天疱疮的特征。与炭疽疫苗相关的不良全身事件主要为流感样症状。此前尚未有接种炭疽疫苗后发生寻常型天疱疮的病例报道。鉴于近期蓄意爆发的炭疽疫情以及生物恐怖主义的持续威胁，炭疽疫苗存在广泛接种的可能性。因此，需要持续观察并记录真正的不良事件。
