接种 ChAdOx1 nCoV-19 疫苗后出现严重寻常型天疱疮：病例报告及文献复习
Development of severe pemphigus vulgaris following ChAdOx1 nCoV-19 vaccination and review of literature.
机构信息
Department of Dermatology, Venereology and Leprosy, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.
出版信息
J Cosmet Dermatol. 2022 Jun;21(6):2311-2314. doi: 10.1111/jocd.14945. Epub 2022 Apr 9.
Abstract
Vaccines are indeed a boon for tackling the present COVID-19 pandemic. In India, ChAdOx1 nCoV-19 (Covishield) is the most commonly used vaccine in the government vaccination program for adults more than 18 years of age. It is a recombinant vaccine developed by Oxford-Astra Zeneca and manufactured in India by Serum Institute of India (SSI). Here, we report a case of severe pemphigus vulgaris following the second dose of ChAdOx1 nCoV-19 vaccination in an adult male. The patient developed septicemia during the course of hospital stay, and he was managed with systemic steroids, parenteral antibiotics, and intravenous immunoglobulins (IVIg) along with proper wound care. Patient started improving within 1 month of therapy. This case is being reported in view of the rarity of pemphigus vulgaris following ChAdOx1 nCoV-19 vaccine.
摘要
疫苗确实是应对当前 COVID-19 大流行的福音。在印度，ChAdOx1 nCoV-19（Covishield）是政府为 18 岁以上成年人接种计划中最常用的疫苗。它是由牛津大学和印度血清研究所（SSI）联合开发的一种重组疫苗。在这里，我们报告了一名成年男性在接种第二剂 ChAdOx1 nCoV-19 后出现严重寻常型天疱疮的病例。患者在住院期间发生败血症，并接受了全身类固醇、静脉内抗生素和静脉注射免疫球蛋白（IVIg）以及适当的伤口护理。患者在治疗 1 个月内开始好转。鉴于接种 ChAdOx1 nCoV-19 疫苗后罕见发生寻常型天疱疮，故报告此病例。
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