Di Pascuale Mario A, Espana Edgar M, Tseng Scheffer C G
Ocular Surface Center, 8780 SW 92 Street, Suite 203, Miami, FL 33176, USA.
Cornea. 2004 Jan;23(1):89-92. doi: 10.1097/00003226-200401000-00016.
To report a case of conjunctiva-cornea intraepithelial neoplasia (CCIN) treated with topical mitomycin C (MMC) and interferon alfa-2b in cycles.
A 52-year-old woman referred for limbal stem cell deficiency and epithelial defect was found instead to have CCIN. The diagnosis was confirmed by impression cytology and treated in cycles with topical 0.02% MMC for 14 days in the first cycle, 12 days in the second cycle, and 3 days in the third cycle followed by topical interferon alfa-2b 1 x 106 U/mL for 11 days.
Topical MMC for 2.5 cycles resulted in 95% reduction of CCIN and improvement of 2 lines of vision. Because of intolerance to MMC, she was switched to topical interferon alfa-2b for 11 days, resulting in total resolution of CCIN, which lasted for at least 10 months.
After differentiation from a persistent corneal epithelial defect and limbal stem cell deficiency by dye staining and impression cytology, the patient in this case of CCIN was successfully treated with topical MMC and interferon alfa-2b in cycles.
报告1例采用局部丝裂霉素C（MMC）和α-2b干扰素循环治疗结膜角膜上皮内瘤（CCIN）的病例。
一名因角膜缘干细胞缺乏和上皮缺损前来就诊的52岁女性，经检查发现患有CCIN。通过印片细胞学检查确诊后，进行循环治疗，第一个周期局部使用0.02% MMC共14天，第二个周期12天，第三个周期3天，随后局部使用1×106 U/mL的α-2b干扰素共11天。
局部使用MMC 2.5个周期使CCIN减少了95%，视力提高了2行。由于对MMC不耐受，改为局部使用α-2b干扰素11天，CCIN完全消退，且持续至少10个月。
通过染料染色和印片细胞学检查与持续性角膜上皮缺损和角膜缘干细胞缺乏相鉴别后，该例CCIN患者采用局部MMC和α-2b干扰素循环治疗取得成功。
