用于眼部酒渣鼻的口服四环素类药物：基于证据的文献综述
Oral tetracyclines for ocular rosacea: an evidence-based review of the literature.
作者信息
Stone Donald U, Chodosh James
机构信息
Molecular Pathogenesis of Eyer Infection Research Center, Dean A. McGee Eye Institute, Department of Ophthalmology, University of Oklahoma Health Sciences Center, 608 Stanton I. Young Boulevard, Oklahoma City, OK 73104, USA.
出版信息
Cornea. 2004 Jan;23(1):106-9. doi: 10.1097/00003226-200401000-00020.
PURPOSE
To review the basis for the use of oral tetracyclines in ocular rosacea.
METHODS
Review of the published literature.
RESULTS
Two prospective, masked, and placebo-controlled studies of oxytetracycline for ocular rosacea demonstrated a modest treatment benefit. Studies performed with tetracycline and doxycycline for ocular rosacea were not placebo controlled, and the optimal drug, dose, and schedule of administration were not evaluated.
CONCLUSIONS
Available evidence supports a moderate treatment benefit in ocular rosacea for oxytetracycline, a tetracycline derivative not currently available in the United States. The efficacies of doxycycline and tetracycline, including treatment effect, optimal dose, duration of therapy, and side effects when used for ocular rosacea have not been established.
目的
回顾口服四环素类药物用于眼部酒渣鼻的依据。
方法
回顾已发表的文献。
结果
两项关于土霉素治疗眼部酒渣鼻的前瞻性、双盲和安慰剂对照研究显示出一定的治疗效果。使用四环素和多西环素治疗眼部酒渣鼻的研究未设安慰剂对照，且未评估最佳药物、剂量和给药方案。
结论
现有证据支持土霉素（一种目前在美国无法获得的四环素衍生物）对眼部酒渣鼻有中度治疗效果。多西环素和四环素用于眼部酒渣鼻的疗效，包括治疗效果、最佳剂量、治疗持续时间和副作用尚未确定。
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