Stevenson William, Chauhan Sunil K, Dana Reza
Department of Ophthalmology, Schepens Eye Research Institute and Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA 02114, USA.
Arch Ophthalmol. 2012 Jan;130(1):90-100. doi: 10.1001/archophthalmol.2011.364.
Dry eye disease is a multifactorial disorder of the tears and ocular surface characterized by symptoms of dryness and irritation. Although the pathogenesis of dry eye disease is not fully understood, it is recognized that inflammation has a prominent role in the development and propagation of this debilitating condition. Factors that adversely affect tear film stability and osmolarity can induce ocular surface damage and initiate an inflammatory cascade that generates innate and adaptive immune responses. These immunoinflammatory responses lead to further ocular surface damage and the development of a self-perpetuating inflammatory cycle. Herein, we review the fundamental links between inflammation and dry eye disease and discuss the clinical implications of inflammation in disease management.
干眼疾病是一种由眼泪和眼表的多因素紊乱所导致的疾病，其特征为眼睛干涩和刺痛症状。尽管干眼疾病的发病机制尚未完全明确，但人们已经认识到炎症在这种使人衰弱的病症的发生和发展过程中起着重要作用。那些对泪膜稳定性和渗透压产生不利影响的因素，可导致眼表损伤，并引发一系列炎症反应，进而产生先天性和适应性免疫反应。这些免疫炎症反应会进一步导致眼表损伤，并形成一个自我持续的炎症循环。在此，我们综述炎症与干眼疾病之间的基本联系，并讨论炎症在疾病管理中的临床意义。
