Rasgon Natalie L, Pumphrey Lara, Prolo Paolo, Elman Shana, Negrao Andre B, Licinio Julio, Garfinkel Alan
Department of Psychiatry and Biobehavioral Sciences, Stanford School of Medicine, Palo Alto, California 94305, USA.
CNS Spectr. 2003 Nov;8(11):805-14. doi: 10.1017/s1092852900019246.
The aim of this study was to develop a mathematical model of the hypothalamo-pituitary-gonadal axis that would reflect available data in humans.
A model of hormonal relationships at the early follicular and midluteal phases of the human menstrual cycle is proposed.
Two distinct temporal patterns of oscillatory behavior have been demonstrated for both pituitary and gonadal steroids in the early follicular phase: first, rapid oscillations in gonadotropin releasing hormone, follicle stimulating hormone and luteinizing hormone (Q approximate to 1 hour) that were an immediate consequence of the programmed equations. Second, there were slower, undulating, emergent rhythms in luteinizing hormone and follicle stimulating hormone, and also in estrogen, having oscillatory periods of 2-12 hours. There was also a longer-period (Q2-3 days) emergent rhythm in progesterone. In the mid-luteal phase, estrogen and progesterone rhythms were correlated, and all hormones showed an approximately 6-hour periodicity.
To our knowledge, the oscillatory behavior of peripheral sex steroids in the follicular phase has not been previously noted.
本研究的目的是建立一个能反映人类现有数据的下丘脑 - 垂体 - 性腺轴数学模型。
提出了一个人类月经周期卵泡早期和黄体中期激素关系模型。
在卵泡早期，垂体和性腺类固醇均表现出两种不同的振荡行为时间模式：第一，促性腺激素释放激素、促卵泡激素和促黄体生成素的快速振荡（Q约为1小时），这是程序方程的直接结果。第二，促黄体生成素、促卵泡激素以及雌激素出现较慢的、起伏的节律，振荡周期为2 - 12小时。孕酮也有一个较长周期（Q为2 - 3天）的出现节律。在黄体中期，雌激素和孕酮节律相关，所有激素均表现出约6小时的周期性。
据我们所知，卵泡期外周性类固醇的振荡行为此前尚未被注意到。
