Grimes E M, Thompson I E, Taymor M L
Acta Endocrinol (Copenh). 1975 Aug;79(4):625-34. doi: 10.1530/acta.0.0790625.
Thirty-one ovulatory women between 20 and 33 years of age were given 150 mug of synthetic LH-RH during different phases of the menstrual cycle. Five patients were studied during the early follicular phase (days 4-7); 10 patients during the late follicular phase (days 9-12); 6 patients during the "LH Surge"; 5 patients during the early luteal phase (days 14-16); 3 patients during mid-luteal phase (days 17-21); and 2 patients during late luteal phase (days 22-27). Oestrogen, progesterone, FSH and LH levels were determined from 30 min prior to LH-RH administration to 90 min thereafter in all cases. LH response to LH-RH increased progressively during the follicular phase. Enhanced pituitary responsiveness to LH-RH occurred at mid-cycle for both LH and FSH and maximum LH responses occurred during the "LH Surge" and early luteal phase. LH responses during the mid and late luteal phases were similar to late follicular phase responses. There were no significant differences between FSH responses during the early follicular, late follicular, mid-luteal and late luteal phases. Maximum pituitary responsiveness appears to occur in a gonadal steroid milieu of high oestrogen levels in association with rising but low progesterone levels. Progesterone or a crucial oestrogen: progesterone ratio may in fact potentiate pituitary release of LH during the early stages of corpus luteum formation. Pituitary responsiveness to LH-RH correlates positively with basal LH and oestrogen levels during the menstrual cycle and with the oestrogen:progesterone ratio during the luteal phase.
31名年龄在20至33岁之间的排卵期女性在月经周期的不同阶段接受了150微克的合成促黄体生成素释放激素（LH-RH）。5名患者在卵泡早期（第4 - 7天）接受研究；10名患者在卵泡晚期（第9 - 12天）；6名患者在“LH峰”期；5名患者在黄体早期（第14 - 16天）；3名患者在黄体中期（第17 - 21天）；2名患者在黄体晚期（第22 - 27天）。在所有病例中，于注射LH-RH前30分钟至注射后90分钟测定雌激素、孕酮、促卵泡生成素（FSH）和促黄体生成素（LH）水平。在卵泡期，LH对LH-RH的反应逐渐增强。在月经周期中期，垂体对LH-RH的反应性增强，LH和FSH均如此，最大LH反应出现在“LH峰”期和黄体早期。黄体中期和晚期的LH反应与卵泡晚期反应相似。卵泡早期、卵泡晚期、黄体中期和黄体晚期的FSH反应之间无显著差异。最大垂体反应性似乎出现在高雌激素水平且孕酮水平上升但较低的性腺类固醇环境中。事实上，孕酮或关键的雌激素：孕酮比值可能在黄体形成早期增强垂体释放LH。垂体对LH-RH的反应性在月经周期中与基础LH和雌激素水平以及黄体期的雌激素：孕酮比值呈正相关。
