Serafín A, Fernández-Zabalegui L, Prats N, Wu Z Y, Roselló-Catafau J, Peralta C
Department of Experimental Pathology, Instituto de Investigaciones Biomédicas de Barcelona-Consejo Superior de Investigaciones Científicas, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain.
Histol Histopathol. 2004 Jan;19(1):281-9. doi: 10.14670/HH-19.281.
Hepatic ischemia-reperfusion (I/R) injury still remains an unresolved problem in both liver resectional surgery and liver transplantation and may be responsible for liver failure, lung injury and death. The current review summarizes the findings reported to date on the effectiveness of ischemic preconditioning against liver and lung damage associated with hepatic I/R injury and the underlying protective mechanisms. The effect of ischemic preconditioning on the mechanisms potentially involved in hepatic I/R injury, including alterations in energy metabolism, neutrophil accumulation, microcirculatory disturbances, formation of proinflammatory mediators, such as endothelin and tumor necrosis factor-alpha, and reactive oxygen species generation have been evaluated. In this review, we address the role of preconditioning in the increased vulnerability of fatty livers to hepatic I/R injury. The effectiveness of ischemic preconditioning versus pharmacological strategies that could simulate the benefits of liver preconditioning has been also discussed.
肝缺血再灌注（I/R）损伤在肝切除手术和肝移植中仍是一个尚未解决的问题，可能导致肝衰竭、肺损伤和死亡。本综述总结了迄今为止报道的关于缺血预处理对与肝I/R损伤相关的肝和肺损伤的有效性及潜在保护机制的研究结果。已评估了缺血预处理对肝I/R损伤潜在相关机制的影响，包括能量代谢改变、中性粒细胞聚集、微循环障碍、促炎介质（如内皮素和肿瘤坏死因子-α）的形成以及活性氧的产生。在本综述中，我们探讨了预处理在脂肪肝对肝I/R损伤易感性增加中的作用。还讨论了缺血预处理与可模拟肝预处理益处的药理学策略相比的有效性。
