Lanius Ruth A, Williamson Peter C, Densmore Maria, Boksman Kristine, Neufeld R W, Gati Joseph S, Menon Ravi S
Department of Psychiatry, University of Western Ontario, London, Canada.
Am J Psychiatry. 2004 Jan;161(1):36-44. doi: 10.1176/appi.ajp.161.1.36.
This study used functional connectivity analyses to assess interregional brain activity correlations during the recall of traumatic memories in traumatized subjects with and without posttraumatic stress disorder (PTSD).
Both 4-T functional magnetic resonance imaging (fMRI) and functional connectivity analyses were used to assess interregional brain activity correlations during script-driven symptom provocation in traumatized subjects with (N=11) and without (N=13) PTSD. Functional connectivity analyses were carried out by using data for brain regions activated in both the PTSD group and the comparison group. The use of functional connectivity analyses in addition to subtraction analyses allowed assessment of specific brain regions involved in the recall of traumatic events and of the neuronal networks underlying the recall of such events.
Significant between-group differences in functional connectivity were found. Comparison of connectivity maps at coordinates x=2, y=20, z=36 (right anterior cingulate gyrus) for the two groups showed that the subjects without PTSD had greater correlation than the PTSD subjects in the left superior frontal gyrus (Brodmann's area 9), left anterior cingulate gyrus (Brodmann's area 32), left striatum (caudate), left parietal lobe (Brodmann's areas 40 and 43), and left insula (Brodmann's area 13). In contrast, the PTSD subjects showed greater correlation than the subjects without PTSD in the right posterior cingulate gyrus (Brodmann's area 29), right caudate, right parietal lobe (Brodmann's areas 7 and 40), and right occipital lobe (Brodmann's area 19).
The differences in brain connectivity between PTSD and comparison subjects may account for the nonverbal nature of traumatic memory recall in PTSD subjects, compared to a more verbal pattern of traumatic memory recall in comparison subjects.
本研究采用功能连接分析，评估有和没有创伤后应激障碍（PTSD）的受创伤受试者在回忆创伤性记忆时脑区之间的活动相关性。
采用4-T功能磁共振成像（fMRI）和功能连接分析，评估有PTSD（N = 11）和无PTSD（N = 13）的受创伤受试者在脚本驱动的症状激发过程中脑区之间的活动相关性。功能连接分析通过使用PTSD组和对照组中均激活的脑区数据进行。除减法分析外使用功能连接分析，能够评估参与创伤事件回忆的特定脑区以及此类事件回忆背后的神经网络。
发现两组之间在功能连接上存在显著差异。对两组在坐标x = 2，y = 20，z = 36（右侧前扣带回）处的连接图谱进行比较，结果显示，无PTSD的受试者在左侧额上回（布罗德曼区9）、左侧前扣带回（布罗德曼区32）、左侧纹状体（尾状核）、左侧顶叶（布罗德曼区40和43）以及左侧岛叶（布罗德曼区13）的相关性高于PTSD受试者。相反，PTSD受试者在右侧后扣带回（布罗德曼区29）、右侧尾状核、右侧顶叶（布罗德曼区7和40）以及右侧枕叶（布罗德曼区19）的相关性高于无PTSD的受试者。
与对照组受试者创伤性记忆回忆的语言模式更强相比，PTSD受试者与对照组受试者在脑连接上的差异可能解释了PTSD受试者创伤性记忆回忆的非语言性质。
