Lanius Ruth A, Williamson Peter C, Hopper James, Densmore Maria, Boksman Kristine, Gupta Madhulika A, Neufeld Robert W J, Gati Joseph S, Menon Ravi S
Department of Psychiatry, University of Western Ontario, London, Ontario, Canada
Biol Psychiatry. 2003 Feb 1;53(3):204-10. doi: 10.1016/s0006-3223(02)01466-x.
The goal of this study was to examine the neuronal circuitry underlying different emotional states (neutral, sad, anxious, and traumatic) in posttraumatic stress disorder (PTSD) in traumatized subjects versus traumatized subjects without PTSD.
Traumatized subjects with (n = 10) and without (n = 10) PTSD were studied using the script-driven symptom provocation paradigm adapted to functional magnetic resonance imaging (fMRI) at a 4 Tesla field strength.
Compared to the trauma-exposed comparison group, PTSD subjects showed significantly less activation of the thalamus and the anterior cingulate gyrus (area 32) in all three emotional states (sad, anxious, and traumatic).
These findings suggest thalamic and anterior cingulate dysfunction in the recollection of traumatic as well as other negative events. Thalamic and anterior cingulate dysfunction may underlie emotion dysregulation often observed clinically in PTSD.
本研究的目的是检查创伤后应激障碍（PTSD）患者与无PTSD的创伤患者在不同情绪状态（中性、悲伤、焦虑和创伤性）下的神经回路。
对患有（n = 10）和未患有（n = 10）PTSD的创伤患者，采用适用于4特斯拉场强功能磁共振成像（fMRI）的脚本驱动症状激发范式进行研究。
与创伤暴露对照组相比，PTSD患者在所有三种情绪状态（悲伤、焦虑和创伤性）下，丘脑和前扣带回（32区）的激活明显较少。
这些发现表明，在回忆创伤性及其他负面事件时，丘脑和前扣带回功能障碍。丘脑和前扣带回功能障碍可能是PTSD临床常见情绪调节障碍的基础。
