Mahajan D K, Billiar R B, Jassani M, Little A B
Am J Obstet Gynecol. 1978 Feb 15;130(4):398-402. doi: 10.1016/0002-9378(78)90279-x.
The effect of ethinyl estradiol treatment on the plasma levels of cortisol, corticosterone, deoxycorticosterone, progesterone, testosterone, dehydroepiandrosterone sulfate, delta4-androstenedione, and estrone was studied in eight women. All the subjects had undergone ovariectomy and hysterectomy at least one year prior to this study. The systemic concentration of cortisol and the binding of cortisol were significantly increased, paralleling the increased transcortin concentration due to ethinyl estradiol treatment. Corticosterone concentration was also significantly increased after three days of estrogen administration and this level continued to be higher than normal as long as patients were treated with estrogens, but there was no change in the plasma concentration of deoxycorticosterone. The plasma levels of progesterone testosterone, dehydroepiandrosterone sulfate, delat4-androstenedione and estrone or the ratio of estrone to delta4-androstenedione did not change with ethinyl estradiol treatment. These observations suggest that the administered estrogen increased the transcortin concentration and had only a limited effect on adrenocortical steroidogenesis.
在八名女性中研究了乙炔雌二醇治疗对血浆皮质醇、皮质酮、脱氧皮质酮、孕酮、睾酮、硫酸脱氢表雄酮、δ4-雄烯二酮和雌酮水平的影响。所有受试者在本研究前至少一年已接受卵巢切除术和子宫切除术。皮质醇的全身浓度和皮质醇的结合显著增加，这与因乙炔雌二醇治疗导致的皮质素浓度增加平行。给予雌激素三天后，皮质酮浓度也显著增加，只要患者接受雌激素治疗，该水平就持续高于正常水平，但脱氧皮质酮的血浆浓度没有变化。乙炔雌二醇治疗后，孕酮、睾酮、硫酸脱氢表雄酮、δ4-雄烯二酮和雌酮的血浆水平或雌酮与δ4-雄烯二酮的比值没有变化。这些观察结果表明，给予的雌激素增加了皮质素浓度，对肾上腺皮质类固醇生成仅有有限的影响。
