Kenworthy Martin N, Kilburn John Paul, Taylor Richard J K
Department of Chemistry, University of York, Heslington, York YO10 5DD, UK.
Org Lett. 2004 Jan 8;6(1):19-22. doi: 10.1021/ol0360039.
[reaction: see text] Highly functionalized l-serine-derived organolithium reagents have been generated and reacted with a variety of electrophiles, delivering novel enantiomerically pure adducts. These adducts were then converted into homochiral amino alcohols and novel nonproteinogenic alpha-amino acids, including an aspartic acid mimic that has been synthesized in an enantiomerically pure form for the first time.
[反应：见正文] 已生成高官能化的L-丝氨酸衍生的有机锂试剂，并使其与多种亲电试剂反应，得到新型对映体纯加合物。然后将这些加合物转化为同手性氨基醇和新型非蛋白质ogenicα-氨基酸，包括首次以对映体纯形式合成的天冬氨酸类似物。
