Ballabh Praveen, Simm Maciej, Kumari Jaishree, Krauss Alfred N, Jain Ajey, Auld Peter A M, Cunningham-Rundles Susanna
Division of Newborn Unit, Westchester Medical Center, Valhalla, New York.
Am J Perinatol. 2003 Nov;20(8):465-75. doi: 10.1055/s-2003-45387.
A key role for inflammation in the etiology of bronchopulmonary dysplasia (BPD) has been proposed. In the present study we have evaluated lymphocyte subpopulations in 39 premature infants with respiratory distress syndrome (RDS) who did or did not develop BPD. The absolute number of lymphocytes was lower among infants with RDS who developed BPD compared with those who did not over the first two weeks of life ( p < 0.020) as were percentage and absolute number of CD4(+) T cells. By contrast, the proportions of CD3(+)CD8(+) lymphocyte cells were not statistically different between non-BPD and BPD infants. B cell percentage was significantly decreased in BPD infants only on day 7. NK "bright" cells (CD56(+)) were highly enriched in all RDS groups. Interestingly, the percentage of CD4(+) T cells expressing CD62L was selectively reduced in BPD infants. As a whole these data suggest that reduction of CD4(+) T cells and especially those important in tissue migration and immune surveillance may be a factor in the pathogenesis of BPD.
炎症在支气管肺发育不良（BPD）病因学中的关键作用已被提出。在本研究中，我们评估了39例患有呼吸窘迫综合征（RDS）且发生或未发生BPD的早产儿的淋巴细胞亚群。与在出生后头两周内未发生BPD的RDS婴儿相比，发生BPD的RDS婴儿的淋巴细胞绝对数量较低（p < 0.020），CD4(+) T细胞的百分比和绝对数量也是如此。相比之下，非BPD和BPD婴儿之间CD3(+)CD8(+)淋巴细胞的比例在统计学上没有差异。仅在第7天，BPD婴儿的B细胞百分比显著降低。NK“亮”细胞（CD56(+)）在所有RDS组中高度富集。有趣的是，在BPD婴儿中，表达CD62L的CD4(+) T细胞百分比选择性降低。总体而言，这些数据表明CD4(+) T细胞减少，尤其是在组织迁移和免疫监视中起重要作用的细胞减少，可能是BPD发病机制中的一个因素。
