Broström E Berggren, Katz-Salamon M, Lundahl J, Halldén G, Winbladh B
Department of Pediatrics, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
Acta Paediatr. 2007 Jan;96(1):23-8. doi: 10.1111/j.1651-2227.2006.00002.x.
We investigated the role of eosinophils in the pathogenesis of bronchopulmonary dysplasia (BPD) in preterm infants.
Fifteen preterm infants with BPD were compared to 13 preterms with respiratory distress syndrome (RDS) and to 16 healthy preterms. We assessed total eosinophil and neutrophil counts in venous blood samples and the levels of the eosinophilic activity markers eosinophilic cationic protein (ECP) and the cellular surface antigen (CD9).
The eosinophil count was greater in BPD compared with RDS and healthy infants (1414 vs. 797 and 471 cells per microlitre, respectively, p = 0.03). ECP levels were elevated (34 vs. 12.8 and 9.8 microg/L, respectively, p = 0.002) and CD9 levels reduced (75 vs. 94 and 86 mean fluorescence intensity units, respectively, p = 0.01) in BPD compared with RDS and healthy infants, suggesting eosinophilic activation in BPD. These findings were not solely explained by differences between gestational age or birth weight of the different groups. ECP levels were positively correlated with the duration of oxygen supplementation in the BPD group. The eosinophil count fell promptly after steroid treatment was commenced in the BPD group.
The findings suggest that BPD is linked to eosinophil activation, which might contribute to the pathogenesis.
我们研究了嗜酸性粒细胞在早产儿支气管肺发育不良（BPD）发病机制中的作用。
将15例患有BPD的早产儿与13例患有呼吸窘迫综合征（RDS）的早产儿以及16例健康早产儿进行比较。我们评估了静脉血样本中的嗜酸性粒细胞和中性粒细胞总数以及嗜酸性粒细胞活性标志物嗜酸性阳离子蛋白（ECP）和细胞表面抗原（CD9）的水平。
与RDS组和健康婴儿相比，BPD组的嗜酸性粒细胞计数更高（分别为每微升1414个细胞、797个细胞和471个细胞，p = 0.03）。与RDS组和健康婴儿相比，BPD组的ECP水平升高（分别为34μg/L、12.8μg/L和9.8μg/L，p = 0.002），CD9水平降低（平均荧光强度单位分别为75、94和86，p = 0.01），提示BPD中嗜酸性粒细胞被激活。这些发现不能单纯用不同组之间的胎龄或出生体重差异来解释。BPD组中ECP水平与吸氧持续时间呈正相关。BPD组开始使用类固醇治疗后嗜酸性粒细胞计数迅速下降。
这些发现提示BPD与嗜酸性粒细胞激活有关，这可能在发病机制中起作用。
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